A facile microwave assisted one-pot strategy for the synthesis of bis-hexahydroquinazolin-5(6H)-ones

被引:0
作者
Saha, Madhusudhan [1 ]
Karim, E. [1 ]
Nongkhlaw, R. L. [2 ]
Vishwakarma, Jai N. [1 ]
机构
[1] St Anthonys Coll, Dept Chem, Organ Res Lab, Shillong 793001, Meghalaya, India
[2] NE Hill Univ, Dept Chem, Shillong 793022, Meghalaya, India
关键词
Bis-hexahydroquinazolin-5(6H)-ones; hexahydroquinazolin-5(6H)-ones; enaminones; cyclocondensation; diamines; formaldehyde; ROUTE;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A facile microwave assisted one-pot synthesis of novel bis-hexahydroquinazolin-5(6H)-ones (7a-j) has been devised by the cyclocondensation of cyclic enaminones (6a-b) with diamines and formaldehyde. The structures of the products have been established with the help of their spectral and analytical data as 3,3'-(alkanediyl/arenediyl)bis-1-benzyl-7,7-dimethyl-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-ones and 3,3'-(alkanediyl/arenediyl)bis-1-benzyl-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-ones.
引用
收藏
页码:117 / 120
页数:4
相关论文
共 11 条
[1]  
Chanda K, 2006, INDIAN J CHEM B, V45, P1076
[2]  
Chanda K, 2004, INDIAN J CHEM B, V43, P2475
[3]  
COATES WJ, 1996, COMPREHENSIVE HETE 2, V6, P225
[4]   A Facile Microwave Assisted One-pot Strategy for the Synthesis of Bis-hexahydroquinazolin-5(6H)-ones [J].
Dutta, Milan Ch. ;
Chanda, Kaushik ;
Nongkhlaw, R. L. ;
Vishwakarma, Jai N. .
E-JOURNAL OF CHEMISTRY, 2010, 7 (01) :281-286
[5]   SYNTHESIS AND ANTI-MALARIAL EFFECTS OF N2-ARYL-N4-[(DIALKYLAMINO)ALKYL]-AND N4-ARYL-N2-[(DIALKYLAMINO)ALKYL]-2,4-QUINAZOLINEDIAMINES [J].
ELSLAGER, EF ;
HESS, C ;
JOHNSON, J ;
ORTWINE, D ;
CHU, V ;
WERBEL, LM .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (02) :127-140
[6]   TMSCl mediated highly efficient one-pot synthesis of octahydroquinazolinone and 1,8-dioxo-octahydroxanthene derivatives [J].
Kantevari, Srinivas ;
Bantu, Rajashaker ;
Nagarapu, Lingaiah .
ARKIVOC, 2006, :136-148
[7]   Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives and evaluation as antibacterials [J].
Kidwai, M ;
Saxena, S ;
Khan, MKR ;
Thukral, SS .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (08) :816-819
[8]   Syntheses of quinazoline-2,4-dione alkaloids and analogues from Mexican Zanthoxylum species [J].
Rivero, IA ;
Espinoza, K ;
Somanathan, R .
MOLECULES, 2004, 9 (07) :609-616
[9]  
Saha M, 2010, ORBITAL, V2, P263
[10]  
Yarim M, 2002, ARZNEIMITTEL-FORSCH, V52, P27