p38 MAP kinase activity modulates αβ T cell development

被引：0
作者：
Mulroy, T
Sen, J
机构：
[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
[2] Childrens Hosp, Dept Pediat, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2001年 / 31卷 / 10期
关键词：
thymus; pre-T cell receptor; signal transduction; p38 MAP kinase;
D O I：
10.1002/1521-4141(2001010)31:10<3056::AID-IMMU3056>3.0.CO;2-B
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Reciprocal interactions between bone marrow derived precursor cells and the thymic environment lead to the generation of the complete repertoire of diverse and functional T cells. We have previously shown that p38 MAP kinase is activated in response to intrathymic signals in thymocytes. In this report we provide evidence that p38 MAP kinase activity is essential for pre-TCR-mediated transition of thymocytes; from the CD4(-) CD8(-) to the CD4(+) CD8(+) stage of development. In the absence of p38 MAP kinase activity differentiation of ap T cells, but not gamma delta T cells, was blocked.
引用
收藏
页码：3056 / 3063
页数：8
相关论文
共 50 条
[1]   p38γ and p38δ Are Involved in T Lymphocyte Development [J].
Risco, Ana ;
Martin-Serrano, Miguel A. ;
Barber, Domingo F. ;
Cuenda, Ana .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[2]   p38 MAP kinase is a mediator of ischemic preconditioning in pigs [J].
Schulz, R ;
Belosjorow, S ;
Gres, P ;
Jansen, J ;
Michel, MC ;
Heusch, G .
CARDIOVASCULAR RESEARCH, 2002, 55 (03) :690-700
[3]   Mechanisms Regulating the Nuclear Translocation of p38 MAP Kinase [J].
Gong, Xiaowei ;
Ming, Xiaoyan ;
Deng, Peng ;
Jiang, Yong .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2010, 110 (06) :1420-1429
[4]   Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions [J].
Tokunaga, Yuji ;
Takeuchi, Koh ;
Takahashi, Hideo ;
Shimada, Ichio .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 21 (08) :704-711
[5]   Purinergic receptor modulation of BV-2 microglial cell activity: Potential involvement of p38 MAP kinase and CREB [J].
Brautigam, VM ;
Frasier, C ;
Nikodemova, M ;
Watters, JJ .
JOURNAL OF NEUROIMMUNOLOGY, 2005, 166 (1-2) :113-125
[6]   Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase [J].
Sawada, Y ;
Nakamura, K ;
Doi, K ;
Takeda, K ;
Tobiume, K ;
Saitoh, M ;
Morita, K ;
Komuro, I ;
De Vos, K ;
Sheetz, M ;
Ichijo, H .
JOURNAL OF CELL SCIENCE, 2001, 114 (06) :1221-1227
[7]   p38 MAP kinases in the heart [J].
Yokota, Tomohiro ;
Wang, Yibin .
GENE, 2016, 575 (02) :369-376
[8]   Molecular determinants that mediate selective activation of p38 MAP kinase isoforms [J].
Enslen, H ;
Brancho, DM ;
Davis, RJ .
EMBO JOURNAL, 2000, 19 (06) :1301-1311
[9]   Kinetic and mechanistic studies of p38α MAP kinase phosphorylation by MKK6 [J].
Wang, Yu-Lu ;
Zhang, Yuan-Yuan ;
Lu, Chang ;
Zhang, Wenhao ;
Deng, Haiteng ;
Wu, Jia-Wei ;
Wang, Jue ;
Wang, Zhi-Xin .
FEBS JOURNAL, 2019, 286 (05) :1030-1052
[10]   Participation of p38 MAP kinase, but not p44/42 MAP kinase, in stimulation of corneal epithelial migration by substance P and IGF-1 [J].
Nakamura, M ;
Chikama, T ;
Nishida, T .
CURRENT EYE RESEARCH, 2005, 30 (10) :825-834
12345