Inhibin and reproductive aging in women

被引：44

作者：

Soules, MR ^{[1
]}

Battaglia, DE ^{[1
]}

Klein, NA ^{[1
]}

机构：

[1] Univ Washington, Dept Obstet & Gynecol, Div Reprod Endocrinol, Seattle, WA 98105 USA

来源：

MATURITAS | 1998年 / 30卷 / 02期

关键词：

aging; inhibin; reproductive potential; menopause;

D O I：

10.1016/S0378-5122(98)00074-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The monotropic FSH rise is the sentinel endocrine event that first indicates a woman is approaching the end of her reproductive potential. While a deficiency in inhibin has long been postulated as the immediate cause of the monotropic FSH rise, this has only recently been demonstrated to actually occur. It is our current hypothesis that when the number of preantral follicles in both ovaries drop below a threshold, then there is a subtle decrease in inhibin B which leads to the monotropic FSH rise which, in turn, accelerates follicular depletion and the attainment of the menopause. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：193 / 204

页数：12

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