Enantiomer separation of drugs by electrokinetic chromatography

被引：123

作者：

Nishi, H

机构：

[1] Analytical Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka 532, 16-89, Kashima 3-chome, Yodogawa-ku

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 735卷 / 1-2期

关键词：

enantiomer separation; reviews; buffer composition; drugs;

D O I：

10.1016/0021-9673(95)01262-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This review surveys the enantiomer separation of drugs by electrokinetic chromatography (EKC). EKC is one option oi capillary electrophoretic (CE) techniques, which permits the separation of electrically neutral drugs. In enantiomer separation by EKC, ionic pseudo-stationary phases such as chiral micelles and proteins, which can migrate with its electrophoretic mobility and can interact with the solutes, are employed as chiral selectors. Addition of electrically neutral chiral selectors such as cyclodextrins and precolumn conversion of solutes into diastereomers are also successful in EKC. A brief theory of separation and modes oi EKC enantiomer separation are described with some typical applications.

引用

收藏

页码：57 / 76

页数：20

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共 152 条

[1] RESOLUTION OF THE ENANTIOMERS OF OXAMNIQUINE BY CAPILLARY ELECTROPHORESIS AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH CYCLODEXTRINS AND HEPARIN AS CHIRAL SELECTORS [J].

ABUSHOFFA, AM ;

CLARK, BJ .

JOURNAL OF CHROMATOGRAPHY A, 1995, 700 (1-2) :51-58

[2] USE OF A MICROEMULSION SYSTEM TO INCORPORATE A LIPOPHILIC CHIRAL SELECTOR IN ELECTROKINETIC CAPILLARY CHROMATOGRAPHY [J].

AIKEN, JH ;

HUIE, CW .

CHROMATOGRAPHIA, 1993, 35 (7-8) :448-450

[3] SEPARATION OF STEREOISOMERS OF AMINOGLUTETHIMIDE USING 3 CAPILLARY ELECTROPHORETIC TECHNIQUES [J].

ANIGBOGU, VC ;

COPPER, CL ;

SEPANIAK, MJ .

JOURNAL OF CHROMATOGRAPHY A, 1995, 705 (02) :343-349

[4] CHIRAL SEPARATION BY CAPILLARY AFFINITY ZONE ELECTROPHORESIS USING AN ALBUMIN-CONTAINING SUPPORT ELECTROLYTE [J].

ARAI, T ;

ICHINOSE, M ;

KURODA, H ;

NIMURA, N ;

KINOSHITA, T .

ANALYTICAL BIOCHEMISTRY, 1994, 217 (01) :7-11

[5] EVALUATION OF THE MACROCYCLIC ANTIBIOTIC VANCOMYCIN AS A CHIRAL SELECTOR FOR CAPILLARY ELECTROPHORESIS [J].

ARMSTRONG, DW ;

RUNDLETT, KL ;

CHEN, JR .

CHIRALITY, 1994, 6 (06) :496-509

[6] HIGHLY ENANTIOSELECTIVE CAPILLARY ELECTROPHORETIC SEPARATIONS WITH DILUTE-SOLUTIONS OF THE MACROCYCLIC ANTIBIOTIC RISTOCETIN-A [J].

ARMSTRONG, DW ;

GASPER, MP ;

RUNDLETT, KL .

JOURNAL OF CHROMATOGRAPHY A, 1995, 689 (02) :285-304

[7] USE OF A MACROCYCLIC ANTIBIOTIC, RIFAMYCIN-B, AND INDIRECT DETECTION FOR THE RESOLUTION OF RACEMIC AMINO-ALCOHOLS BY CE [J].

ARMSTRONG, DW ;

RUNDLETT, K ;

REID, GL .

ANALYTICAL CHEMISTRY, 1994, 66 (10) :1690-1695

[8] ENANTIOMERIC DIFFERENTIATION OF A WIDE-RANGE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES BY CYCLODEXTRIN-MODIFIED MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY USING A BILE-SALT [J].

AUMATELL, A ;

WELLS, RJ .

JOURNAL OF CHROMATOGRAPHY A, 1994, 688 (1-2) :329-337

[9] ENANTIOMERIC DIFFERENTIATION OF A WIDE-RANGE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES BY CAPILLARY ELECTROPHORESIS USING MODIFIED BETA-CYCLODEXTRINS [J].

AUMATELL, A ;

WELLS, RJ ;

WONG, DKY .

JOURNAL OF CHROMATOGRAPHY A, 1994, 686 (02) :293-307

[10] USE OF AFFINITY CAPILLARY ELECTROPHORESIS TO DETERMINE KINETIC AND EQUILIBRIUM-CONSTANTS FOR BINDING OF ARYLSULFONAMIDES TO BOVINE CARBONIC-ANHYDRASE [J].

AVILA, LZ ;

CHU, YH ;

BLOSSEY, EC ;

WHITESIDES, GM .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (01) :126-133

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