In this study, we synthesized the new spirobifluorene derivatives; hexylbiphenyl-spirobifluorene (HBP-Spiro) and demonstrated the operation of a distributed-feedback polymer waveguide blue laser. In addition, we investigated the optical and lasing properties of spirobifluorene derivatives including photostability. The maximum experimental slope efficiency and the energy threshold of a HBP-Spiro-doped waveguide laser were 3.6% and 1.9 mu J, respectively. An operation lifetime of 27,000 shots was obtained for a pump-pulse duration of 1.2 ns and energy of 3.0 mu J at a wavelength of 355 nm.