The chemical toxicology of 2-deoxyribose oxidation in DNA

被引：156

作者：

Dedon, Peter C. ^{[1
]}

机构：

[1] MIT, Ctr Environm Hlth Sci, Cambridge, MA 02139 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2008年 / 21卷 / 01期

关键词：

D O I：

10.1021/tx700283c

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Damage to DNA and RNA caused by oxidative mechanisms has been well-studied for its potential role in the development of human disease. Only recently, though, have we begun to appreciate that oxidation of the 2-deoxyribose moiety in DNA is also a determinant of the genetic toxicology of oxidative stress and inflammation, with involvement in more than just "strand breaks", such as complex DNA lesions, protein-DNA cross-links, and protein and DNA adducts. As an update to a 1992 review of 2'-deoxyribose oxidation by bleomycin and the enediynes published in Chemical Research in Toxicology [Dedon, P. C., and Goldberg, I. H. (1992) Chem. Res. Toxicol. 5, 311-332], this review focuses on recent developments in the chemical biology, bioanalytical chemistry, and genetic, toxicology of 2-deoxyribose oxidation products in DNA under biologically relevant conditions.

引用

页码：206 / 219

页数：14

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