Studies on the synthesis of 3-methyl-6-(substituted-urea/-thiourea)-2(3H)-benzothiazolone derivatives and antimicrobial activities

被引：0

作者：

Unal, Ayse Sibel ^{[1
]}

Onurdag, Fatma Kaynak ^{[2
]}

Ozgen, Selda ^{[3
]}

Dogruer, Deniz ^{[4
]}

Onkol, Tijen ^{[4
]}

机构：

[1] Ulkar Kimya Sanayi & Ticaret AS, TR-59500 Cerkezkoy Tekirdag, Turkey

[2] Trakya Univ, Fac Pharm, Dept Microbiol, TR-22030 Edirne, Turkey

[3] Gazi Univ, Fac Pharm, Dept Microbiol, TR-06330 Ankara, Turkey

[4] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Ankara, Turkey

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2015年 / 54卷 / 02期

关键词：

2(3H)-Benzothiazolone; urea; thiourea; antimicrobial; antitubercular activity; BIOLOGICAL EVALUATION; THIOUREA; UREA; TUBERCULOSIS; RESISTANCE; AGENTS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of sixteen new urea and thiourea derivatives at position 6 of 3-methyl-2(3H)-benzothiazolone ring have been prepared and studied using 1R, H-1 NMR, mass spectra and elemental analysis. The urea and thiourea derivatives have been obtained by the reaction of 6-amino-3-methyl-2(3H)-benzothiazolone with appropriate isocyanates and isothiocyanates. The antibacterial, antifungal and antimycobacterial activities of the synthesized compounds have been evaluated in vitro using microdilution and microplate methods.

引用

页码：253 / 259

页数：7

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