Chemical derivatization for enhancing sensitivity during LC/ESI-MS/MS quantification of steroids in biological samples: a review

被引：73
作者：
Higashi, Tatsuya [1 ]
Ogawa, Shoujiro [1 ]
机构：
[1] Tokyo Univ Sci, Fac Pharmaceut Sci, 2641 Yamazaki, Noda, Chiba 2788510, Japan
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2016年 / 162卷
关键词：
Chemical derivatization; LC/ESI-MS/MS; Endogenous steroid; Biological sample; Sensitivity; Stable isotope-coded derivatization; TANDEM MASS-SPECTROMETRY; LC-ESI-MS/MS; VITAMIN-D METABOLITES; DRIED BLOOD SPOTS; ATMOSPHERIC-PRESSURE PHOTOIONIZATION; ISOTOPE-CODED DERIVATIZATION; LEMLI-OPITZ-SYNDROME; LIQUID-CHROMATOGRAPHY; ELECTROSPRAY-IONIZATION; HUMAN SERUM;
D O I：
10.1016/j.jsbmb.2015.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sensitive and specific methods for the detection, characterization and quantification of endogenous steroids in body fluids or tissues are necessary for the diagnosis, pathological analysis and treatment of many diseases. Recently, liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) has been widely used for these purposes due to its specificity and versatility. However, the ESI efficiency and fragmentation behavior of some steroids are poor, which lead to a low sensitivity. Chemical derivatization is one of the most effective methods to improve the detection characteristics of steroids in ESI-MS/MS. Based on this background, this article reviews the recent advances in chemical derivatization for the trace quantification of steroids in biological samples by LC/ESI-MS/MS. The derivatization in ESI-MS/MS is based on tagging a proton-affinitive or permanently charged moiety on the target steroid. Introduction/formation of a fragmentable moiety suitable for the selected reaction monitoring by the derivatization also enhances the sensitivity. The stable isotope-coded derivatization procedures for the steroid analysis are also described. (C) 2015 Elsevier Ltd. All rights reserved.
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页码：57 / 69
页数：13
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