Further evidence of antigenic drift and protective efficacy afforded by a recombinant HVT-H5 vaccine against challenge with two antigenically divergent Egyptian clade 2.2.1 HPAI H5N1 strains

被引：63

作者：

Rauw, F. ^{[1
]}

Palya, V. ^{[2
]}

Van Borm, S. ^{[1
]}

Welby, S. ^{[1
]}

Tatar-Kis, T. ^{[2
]}

Gardin, Y. ^{[3
]}

Dorsey, K. Moore

Aly, M. M. ^{[4
]}

Hassan, M. K. ^{[4
]}

Soliman, M. A. ^{[4
]}

Lambrecht, B. ^{[1
]}

van den Berg, T. ^{[1
]}

机构：

[1] Vet & Agrochem Res Ctr VAR, Avian Virol & Immunol Unit, B-1180 Brussels, Belgium

[2] CEVA Phylaxia, H-1107 Budapest, Hungary

[3] CEVA Sante Anim, F-33501 Libourne, France

[4] Anim Hlth Res Inst, Giza 12618, Egypt

来源：

VACCINE | 2011年 / 29卷 / 14期

关键词：

Influenza; Chicken; H5N1; Egypt; Vaccination; PATHOGENIC AVIAN INFLUENZA; NEWCASTLE-DISEASE VIRUS; MAREKS DISEASES; SEED STRAIN; CHICKENS; HERPESVIRUS; IMMUNITY; TURKEYS; FUSION; VECTOR;

D O I：

10.1016/j.vaccine.2011.01.048

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we have compared the protection afforded by a recombinant turkey herpesvirus vaccine expressing the H5 gene from a clade 2.2 H5N1 strain (rHVT-H5) and a Mexican-origin H5N2 inactivated vaccine, alone or in combination, against two antigenically divergent H5N1 Egyptian strains isolated in 2007 and 2008. Our results confirm the existence of a major antigenic drift among the Egyptian H5N1 strains such that, although protection against the "classical" 2007 HPAI H5N1 Egyptian strain could be obtained with both types of vaccines, only vaccination with the rHVT-H5 vaccine protected against challenge with the "variant" 2008 HPAI H5N1 Egyptian strain. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2590 / 2600

页数：11

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