The relationship between basal and luminal cytokeratins with histopathologic characteristics of canine mammary gland cancer

被引：0
作者：
Eivani, D. [1 ]
Mortazavi, P. [1 ]
机构：
[1] Islamic Azad Univ, Fac Specialized Vet Sci, Dept Pathol, Sci & Res Branch, Tehran, Iran
来源：
POLISH JOURNAL OF VETERINARY SCIENCES | 2016年 / 19卷 / 02期
关键词：
canine mammary gland tumors; basal cytokeratin; luminal cytokeratin; CLINICOPATHOLOGICAL FEATURES; CADHERIN EXPRESSION; TUMORS; BREAST; CLASSIFICATION; CARCINOMA; CELLS; IDENTIFICATION; PROGNOSIS;
D O I：
10.1515/pjvs-2016-0033
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Neoplasia occurs mostly in mammary glands in female dogs and mammary gland cancer is one of the causes of death in these animals cytokeratins are one of the most important of tumor markers for identification of tumor prognosis. In this study, 120 canine malignant tumor samples of mammary glands were studied. From each sample, a section was taken for hematoxylin-eosin staining and two sections for immunohistochemical staining of markers CK5/6 and CK7. Histopathology slides was evaluated by light microscope. The results show that the presence of markers CK7 and CK5/6 had no significant relationship with tumor grade and type (p<0.05). However, it seems that unlike humans, CK5/6 and CK7 is not an independent prognostic factor in canine mammary gland tumors.
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页码：261 / 269
页数：9
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