Discriminating Lyme Neuroborreliosis from Other Neuroinflammatory Diseases by Levels of CXCL13 in Cerebrospinal Fluid

被引：69

作者：

van Burgel, N. D. ^{[1
]}

Bakels, F. ^{[2
]}

Kroes, A. C. M. ^{[1
]}

van Dam, A. P. ^{[3
]}

机构：

[1] Leiden Univ Med Ctr, Dept Med Microbiol, Ctr Infect Dis, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands

[3] OLVG Hosp, Dept Med Microbiol, NL-1090 HM Amsterdam, Netherlands

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 05期

关键词：

CHEMOKINE CXCL13; DIAGNOSIS; MARKER; INFECTION;

D O I：

10.1128/JCM.00084-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

liosis (LNB). Levels of intrathecal CXCL13 were determined for 58 LNB patients and 210 controls; sensitivity was 88% and specificity was 89% (cutoff, 250 pg of CXCL13/ml of CSF). Elevated levels of CXCL13 can aid in the diagnosis of LNB, but levels should be interpreted with care.

引用

页码：2027 / 2030

页数：4

共 13 条

[1] Relevance of the antibody index to diagnose Lyme neuroborreliosis among seropositive patients [J].

Blanc, F. ;

Jaulhac, B. ;

Fleury, M. ;

de Seze, J. ;

de Martino, S. J. ;

Remy, V. ;

Blaison, G. ;

Hansmann, Y. ;

Christmann, D. ;

Tranchant, C. .

NEUROLOGY, 2007, 69 (10) :953-958

[2] Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection [J].

Cagigi, Alberto ;

Mowafi, Frida ;

Dang, Linh V. Phuong ;

Tenner-Racz, Klara ;

Atlas, Ann ;

Grutzmeier, Sven ;

Racz, Paul ;

Chiodi, Francesca ;

Nilsson, Anna .

BLOOD, 2008, 112 (12) :4401-4410

[3] CSFB -: lymphocyte chemoattractant (CXCL13) in the early diagnosis of acute Lyme neuroborreliosis [J].

Ljostad, Unn ;

Mygland, Ase .

JOURNAL OF NEUROLOGY, 2008, 255 (05) :732-737

[4] EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis [J].

Mygland, A. ;

Ljostad, U. ;

Fingerle, V. ;

Rupprecht, T. ;

Schmutzhard, E. ;

Steiner, I. .

EUROPEAN JOURNAL OF NEUROLOGY, 2010, 17 (01) :8-+

[5] Cytokine CXCL13 - A possible early CSF marker for neuroborreliosis [J].

Rupprecht T. ;

Koedel U. ;

Angele B. ;

Fingerle V. ;

Pfister H.-W. .

Der Nervenarzt, 2006, 77 (4) :470-473

[6] The chemokine CXCL13 (BLC): A putative diagnostic marker for neuroborreliosis [J].

Rupprecht, TA ;

Pfister, HW ;

Angele, B ;

Kastenbauer, S ;

Wilske, B ;

Koedel, U .

NEUROLOGY, 2005, 65 (03) :448-450

[7]

SCHIFFER L, LUPUS, DOI DOI 10.1177/0961203310383301

[8] B-cell-attracting chemokine CXCL13 as a marker of disease activity and renal involvement in systemic lupus erythematosus (SLE) [J].

Schiffer, Lena ;

Kuempers, Philipp ;

Davalos-Misslitz, Ana. M. ;

Haubitz, Marion ;

Haller, Hermann ;

Anders, Hans-Joachim ;

Witte, Torsten ;

Schiffer, Mario .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (12) :3708-3712

[9] Sublime diagnosis of Lyme neuroborreliosis [J].

Segal, BM ;

Logigian, EL .

NEUROLOGY, 2005, 65 (03) :351-352

[10] Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS [J].

Sellebjerg, F. ;

Bornsen, L. ;

Khademi, M. ;

Krakauer, M. ;

Olsson, T. ;

Frederiksen, J. L. ;

Sorensen, P. S. .

NEUROLOGY, 2009, 73 (23) :2003-2010

← 1 2 →