Telomere shortening in human HL60 cells by treatment with 3′-azido-2′,3′-dideoxynucleosides and telomerase inhibition by their 5′-triphosphates

被引：7

作者：

Liu, Xiaohong ^{[2
]}

Inomata, Motoko ^{[2
]}

Ogawara, Tsukasa ^{[1
]}

Saneyoshi, Mineo ^{[1
,2
]}

Yamaguchi, Toyofumi ^{[1
,2
]}

机构：

[1] Teikyo Univ Sci & Technol, Dept Biosci, Yamanashi 4090193, Japan

[2] Teikyo Univ Sci & Technol, Biotechnol Res Ctr, Yamanashi 4090193, Japan

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2007年 / 26卷 / 8-9期

关键词：

telomerase; reverse transcriptase; telomere shortening; nucleoside analogues; 2-amino-3'-azido-2'; 3'-dideoxyadenosine;

D O I：

10.1080/15257770701515468

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomerase is thought to play an important role in the mechanism of tumor cell immortalization by maintenance of telomere length. To obtain information on the susceptibility of telomerase to nucleoside analogues, the effects of base-modified 3'-azido-2',3'-dideoxynucleoside lriphosphates on the enzyme were investigated. It is suggested that the 2-amino group of the nucleotide purine nucleus is important for the inhibitory activity. Telomere shortening caused by long-term treatment with these nucleosides is also described.

引用

页码：1067 / 1071

页数：5

共 4 条

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