Molecular and Immunohistochemical Markers with Prognostic and Predictive Significance in Liver Metastases from Colorectal Carcinoma

被引：13

作者：

Lopez, Gianluca ^{[1
]}

Boggio, Francesca ^{[1
]}

Ferrero, Stefano ^{[1
,2
]}

Fusco, Nicola ^{[1
,2
]}

Del Gobbo, Alessandro ^{[1
]}

机构：

[1] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Div Pathol, Via Francesco Sforza 35, I-20122 Milan, Italy

[2] Univ Milan, Dept Biomed Surg & Dent Sci, Via Francesco Sforza 35, I-20122 Milan, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 10期

关键词：

biomarkers; immunohistochemistry; molecular markers; colorectal cancer; liver metastases; prognostic; predictive; FOLATE RECEPTOR-ALPHA; CANCER PATIENTS; POOR-PROGNOSIS; CLINICAL-SIGNIFICANCE; BRAF MUTATIONS; PRIMARY TUMORS; BETA-CATENIN; COLON-CANCER; TGF-BETA; C-MET;

D O I：

10.3390/ijms19103014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite the significant recent achievements in the diagnosis and treatment of colorectal cancer (CRC), the prognosis of these patients has currently plateaued. During the past few years, the opportunity to consider multiple treatment modalities (including surgery and other locoregional treatments, systemic therapy, and targeted therapy) led to the research of novel prognostic and predictive biomarkers in CRC liver metastases (CRCLM) patients. In this review, we seek to describe the current state of knowledge of CRCLM biomarkers and to outline impending clinical perspectives, in particular focusing on the cutting-edge tools available for their characterization.

引用

页数：18

共 111 条

[1] Role of surgery in colorectal cancer liver metastases [J].

Akgul, Ozgur ;

Cetinkaya, Erdinc ;

Ersoz, Siyar ;

Tez, Mesut .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (20) :6113-6122

[2] In Vitro and In Vivo Activity of IMGN853, an Antibody-Drug Conjugate Targeting Folate Receptor Alpha Linked to DM4, in Biologically Aggressive Endometrial Cancers [J].

Altwerger, Gary ;

Bonazzoli, Elena ;

Bellone, Stefania ;

Egawa-Takata, Tomomi ;

Menderes, Gulden ;

Pettinella, Francesca ;

Bianchi, Anna ;

Riccio, Francesco ;

Feinberg, Jacqueline ;

Zammataro, Luca ;

Han, Chanhee ;

Yadav, Ghanshyam ;

Dugan, Katherine ;

Morneault, Ashley ;

Ponte, Jose F. ;

Buza, Natalia ;

Hui, Pei ;

Wong, Serena ;

Litkouhi, Babak ;

Ratner, Elena ;

Silasi, Dan-Arin ;

Huang, Gloria S. ;

Azodi, Masoud ;

Schwartz, Peter E. ;

Santin, Alessandro D. .

MOLECULAR CANCER THERAPEUTICS, 2018, 17 (05) :1003-1011

[3] Stromal cell derived factor-1 and CXCR4 expression in colorectal cancer promote liver metastasis [J].

Amara, Sameh ;

Chaar, Ines ;

Khiari, Meriem ;

Ounissi, Donia ;

Weslati, Marwa ;

Boughriba, Rahma ;

Hmida, Abdelmajid B. ;

Bouraoui, Saadia .

CANCER BIOMARKERS, 2015, 15 (06) :869-879

[4]

[Anonymous], CANC TODAY

[5] Implication of the Galectin-3 in colorectal cancer development (about 325 Tunisian Patients) [J].

Arfaoui-Toumi, A. ;

Kria-Ben Mahmoud, L. ;

Ben Hmida, M. ;

Khalfallah, M. -T. ;

Regaya-Mzabi, S. ;

Bouraoui, S. .

BULLETIN DU CANCER, 2010, 97 (02) :E1-E8

[6]

Asano Masatake, 2011, J Oral Sci, V53, P147

[7] EMX2 gene expression predicts liver metastasis and survival in colorectal cancer [J].

Aykut, Berk ;

Ochs, Markus ;

Radhakrishnan, Praveen ;

Brill, Adrian ;

Hoecker, Hermine ;

Schwarz, Sandra ;

Weissinger, Daniel ;

Kehm, Roland ;

Kulu, Yakup ;

Ulrich, Alexis ;

Schneider, Martin .

BMC CANCER, 2017, 17

[8] Emergence of KRAS-mutation in liver metastases after an anti-EGFR treatment in patient with colorectal cancer: Are we aware of the therapeutic impact of intratumor heterogeneity? [J].

Baretti, M. ;

Personenia, N. ;

Destro, A. ;

Santoro, A. ;

Rimassa, L. .

CANCER BIOLOGY & THERAPY, 2018, 19 (08) :659-663

[9] miR-146a targets c-met and abolishes colorectal cancer liver metastasis [J].

Bleau, Anne-Marie ;

Redrado, Miriam ;

Nistal-Villan, Estanislao ;

Villalba, Maria ;

Exposito, Francisco ;

Redin, Esther ;

de Aberasturi, Arrate L. ;

Larzabal, Leyre ;

Freire, Javier ;

Gomez-Roman, Javier ;

Calvo, Alfonso .

CANCER LETTERS, 2018, 414 :257-267

[10] IDENTIFICATION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR AS THE C-MET PROTOONCOGENE PRODUCT [J].

BOTTARO, DP ;

RUBIN, JS ;

FALETTO, DL ;

CHAN, AML ;

KMIECIK, TE ;

VANDEWOUDE, GF ;

AARONSON, SA .

SCIENCE, 1991, 251 (4995) :802-804

← 1 2 3 4 5 6 7 8 9 10 →