Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

被引：20

作者：

Hofler, Georg T. ^{[1
]}

But, Andrada ^{[1
]}

Younes, Sabry H. H. ^{[1
,2
]}

Wever, Ron ^{[3
]}

Paul, Caroline E. ^{[1
]}

Arends, Isabel W. C. E. ^{[4
]}

Hollmann, Frank ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Biotechnol, NL-2629 HZ Delft, Netherlands

[2] Sohag Univ, Fac Sci, Dept Chem, Sohag 82524, Egypt

[3] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1090 GD Amsterdam, Netherlands

[4] Univ Utrecht, Fac Sci, NL-3584 CD Utrecht, Netherlands

来源：

ACS SUSTAINABLE CHEMISTRY & ENGINEERING | 2020年 / 8卷 / 07期

基金：

欧洲研究理事会;

关键词：

Chemoenzymatic halocyclization; Preparative scale; Haloperoxidase; HYDROGEN-PEROXIDE; VANADIUM CHLOROPEROXIDASE; ENVIRONMENTAL ASSESSMENT; SODIUM-BROMIDE; CATALYST; GREEN; H2O2;

D O I：

10.1021/acssuschemeng.9b07494

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.

引用

页码：2602 / 2607

页数：11

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