SETTING: Since 1992, tuberculosis (TB) control measures have reduced incidence rates in New York City and elsewhere. Nevertheless, trends have not been uniform in all demographic groups. OBJECTIVE: To characterize the epidemiology of human immunodeficiency virus (HIV) associated TB in New York during the 1990s, we analyzed social, demographic and clinical characteristics and genetic data on Mycobacterium tuberculosis isolates among persons with known HIV-status. DESIGN: A retrospective case-control study to compare patients with HIV-associated TB and patients with TB alone. RESULTS: Of 546 patients (70.5%) in the Department of Health Tuberculosis Control Registry treated for TB, 385 also had documented HIV status; 198 were HIV-infected (51%) and 187 (49%) were not. Genotype analysis of the 385 M. tuberculosis isolates identified 200 (52%) clustered strains, representing recent transmission. Although the overall percentage of TB cases associated with restriction fragment length polymorphism (RFLP) clustering fell over the period studied, HIV-associated cases were still much more likely to be associated with clustering than non-HIV-associated cases. CONCLUSIONS: Continued attention is required to contain the spread of TB in this vulnerable population.
机构:
SUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
SUNY Albany, Rockefeller Coll Publ Affairs & Policy, Albany, NY 12222 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
Martin, Erika G.
MacDonald, Roderick H.
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SUNY Albany, Rockefeller Coll Publ Affairs & Policy, Albany, NY 12222 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
MacDonald, Roderick H.
Smith, Lou C.
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SUNY Albany, Sch Publ Hlth, Albany, NY 12222 USA
New York State Dept Hlth, AIDS Inst, Albany, NY 12237 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
Smith, Lou C.
Gordon, Daniel E.
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New York State Dept Hlth, AIDS Inst, Albany, NY 12237 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
Gordon, Daniel E.
Lu, Tao
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SUNY Albany, Sch Publ Hlth, Albany, NY 12222 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
Lu, Tao
O'Connell, Daniel A.
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h-index: 0
机构:
New York State Dept Hlth, AIDS Inst, Albany, NY 12237 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
机构:
SUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
SUNY Albany, Rockefeller Coll Publ Affairs & Policy, Albany, NY 12222 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
Martin, Erika G.
MacDonald, Roderick H.
论文数: 0引用数: 0
h-index: 0
机构:
SUNY Albany, Rockefeller Coll Publ Affairs & Policy, Albany, NY 12222 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
MacDonald, Roderick H.
Smith, Lou C.
论文数: 0引用数: 0
h-index: 0
机构:
SUNY Albany, Sch Publ Hlth, Albany, NY 12222 USA
New York State Dept Hlth, AIDS Inst, Albany, NY 12237 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
Smith, Lou C.
Gordon, Daniel E.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, AIDS Inst, Albany, NY 12237 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
Gordon, Daniel E.
Lu, Tao
论文数: 0引用数: 0
h-index: 0
机构:
SUNY Albany, Sch Publ Hlth, Albany, NY 12222 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA
Lu, Tao
O'Connell, Daniel A.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, AIDS Inst, Albany, NY 12237 USASUNY, Nelson A Rockefeller Inst Govt, New York, NY USA