Does lacosamide aggravate Lennox-Gastaut syndrome? Report on three consecutive cases

被引：29

作者：

Cuzzola, Antonella ^{[2
,3
]}

Ferlazzo, Edoardo ^{[1
]}

Italiano, Domenico ^{[1
]}

Calabro, Rocco Salvatore ^{[1
]}

Bramanti, Placido ^{[1
]}

Genton, Pierre ^{[2
]}

机构：

[1] IRCCS Ctr Neurolesi Bonino Pulejo, I-98124 Messina, Italy

[2] Hop Henri Gastaut, Ctr St Paul, Marseille, France

[3] Univ Messina, Div Child Neurol & Psychiat, Messina, Italy

来源：

EPILEPSY & BEHAVIOR | 2010年 / 19卷 / 04期

关键词：

Lennox-Gastaut syndrome; Lacosamide; PARTIAL-ONSET SEIZURES; CARBAMAZEPINE; EFFICACY; SAFETY; TRIAL; DRUG;

D O I：

10.1016/j.yebeh.2010.09.024

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Lennox-Gastaut syndrome is an intractable epileptic encephalopathy, with most patients experiencing daily seizures despite therapy with multiple antiepileptic drugs. New treatments need to be tested to define their efficacy in this syndrome. Lacosamide is a new antiepileptic drug recently approved for the treatment of partial-onset seizures. We describe three patients with Lennox-Gastaut syndrome resistant to conventional antiepileptic drugs whose seizures were aggravated by lacosamide. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：650 / 651

页数：2

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