Isoleucilactucin Ameliorates Coal Fly Ash-Induced Inflammation through the NF-κB and MAPK Pathways in MH-S Cells

被引：6

作者：

Ullah, H. M. Arif ^{[1
]}

Kwon, Tae-Hyung ^{[2
]}

Park, SeonJu ^{[3
]}

Kim, Sung Dae ^{[1
]}

Rhee, Man Hee ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu 41566, South Korea

[2] Chuncheon Bioind Fdn CBF, Dept Res & Dev, Chunchon 24232, South Korea

[3] Korea Basic Sci Inst KBSI, Chuncheon Ctr, Chunchon 24341, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 17期

关键词：

lung macrophages; isoleucilactucin; anti-inflammatory properties; NF-kappa B pathway; AMPK pathway; NITRIC-OXIDE SYNTHASE; TRANSCRIPTION FACTOR; PARTICULATE MATTER; SESQUITERPENE LACTONE; AIR-POLLUTION; EXPRESSION; COX-2; ALPHA; INOS; INTERVENTION;

D O I：

10.3390/ijms22179506

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated whether isoleucilactucin, an active constituent of Ixeridium dentatum, reduces inflammation caused by coal fly ash (CFA) in alveolar macrophages (MH-S). The anti-inflammatory effects of isoleucilactucin were assessed by measuring the concentration of nitric oxide (NO) and the expression of pro-inflammatory mediators in MH-S cells exposed to CFA-induced inflammation. We found that isoleucilactucin reduced CFA-induced NO generation dose-dependently in MH-S cells. Moreover, isoleucilactucin suppressed CFA-activated proinflammatory mediators, including cyclooxygenase-2 (COX2) and inducible NO synthase (iNOS), and the proinflammatory cytokines such as interleukin-(IL)-1 beta, IL-6, and tumor necrosis factor (TNF-alpha). The inhibiting properties of isoleucilactucin on the nuclear translocation of phosphorylated nuclear factor-kappa B (p-NF-kappa B) were observed. The effects of isoleucilactucin on the NF-kappa B and mitogen-activated protein kinase (MAPK) pathways were also measured in CFA-stimulated MH-S cells. These results indicate that isoleucilactucin suppressed CFA-stimulated inflammation in MH-S cells by inhibiting the NF-kappa B and MAPK pathways, which suggest it might exert anti-inflammatory properties in the lung.

引用

页数：12

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