Parallels Between the Antiviral State and the Irradiated State

被引：4

作者：

McGee, Heather M. ^{[1
]}

Marciscano, Ariel E. ^{[2
]}

Campbell, Allison M. ^{[3
]}

Monjazeb, Arta M. ^{[4
]}

Kaech, Susan M. ^{[1
]}

Teijaro, John R. ^{[5
]}

机构：

[1] Salk Inst Biol Studies, NOMIS Ctr Immunobiol & Microbial Pathogenesis, La Jolla, CA 92037 USA

[2] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY USA

[3] Yale Sch Med, Dept Therapeut Radiol, New Haven, CT USA

[4] UC Davis Comprehens Canc Ctr, Dept Radiat Oncol, Sacramento, CA USA

[5] Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2021年 / 113卷 / 08期

关键词：

CD8; T-CELLS; NF-KAPPA-B; I INTERFERON; TUMOR-CELLS; ANTITUMOR IMMUNITY; DENDRITIC CELLS; STRANDED-RNA; RADIATION; MEMORY; VIRUS;

D O I：

10.1093/jnci/djaa190

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Improved understanding of host antiviral defense and antitumor immunity have elucidated molecular pathways important to both processes. During viral infection, RNA or DNA in the host cell serves as a danger signal that initiates the antiviral response. Recent studies have elucidated similarities in the signaling pathways activated by viruses and the signaling pathways induced by tumor DNA that is released into the cytoplasm of irradiated tumor cells. Both the host defense to viral infection and the sterile inflammation provoked by radiotherapy induce a type I interferon response that is necessary for pathogen control and immune-mediated tumor control, respectively. These findings have led to the hypothesis that radiotherapy employs a form of viral mimicry.

引用

页码：969 / 979

页数：11

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