Vasopeptidase inhibitors: an emerging class of cardiovascular drugs

被引：45
作者：
Bralet, J [1 ]
Schwartz, JC
机构：
[1] Univ Dijon, Fac Pharm, F-21033 Dijon, France
[2] INSERM, Ctr Paul Broca, Inst Univ France, F-75014 Paris, France
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 03期
关键词：
D O I：
10.1016/S0165-6147(00)01644-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Vasopeptidase inhibitors (VPIs) inhibit both angiotensin-converting enzyme (ACE) and neprilysin (NEP) and can thus reduce the activity of the renin-angiotensin system and potentiate the vasodilatory, natriuretic and antiproliferative effects of bradykinin and natriuretic peptides, In preclinical studies, VPIs display a large profile being effective in all tested models of hypertension and in heart failure, and ongoing clinical studies suggest th at VPIs possess advantages over other therapies.
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页码：106 / 109
页数：6
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