Interest of immunohistochemistry for the diagnosis of benign hepatocellular tumors

被引：3
|
作者：
Bioulac-Sage, Paulette [1 ,2 ]
Balabaud, Charles [2 ,3 ]
Zucman-Rossi, Jessica [4 ]
机构：
[1] CHU Bordeaux, Hop Pellegrin, Serv Pathol, F-33076 Bordeaux, France
[2] Univ Bordeaux 2, Grp Rech Etud Foie, INSERM, U889, F-33076 Bordeaux, France
[3] Hop St Andre, Serv Hepatol, F-33075 Bordeaux, France
[4] INSERM, U674, F-75010 Paris, France
来源：
ANNALES DE PATHOLOGIE | 2010年 / 30卷 / 06期
关键词：
Focal nodular hyperplasia; Hepatocellular adenoma; Immunohistochemistry; Glutamine synthetase; beta-catenin; LFABP; C reactive protein; Serum amyloid A; FOCAL NODULAR HYPERPLASIA; LIVER ADENOMATOSIS; HEPATIC ADENOMAS; INACTIVATION; CLASSIFICATION; IDENTIFICATION; ACTIVATION; EXPRESSION; MANAGEMENT; MUTATIONS;
D O I：
10.1016/j.annpat.2010.10.005
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
In this review, we focus on the interest of immunohistochemistry first, to differentiate the two types of benign hepatocellular nodules: focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) and second, to recognize the different subtypes of HCA: HNF1 alpha inactivated HCA, beta-catenin activated HCA and inflammatory HCA. This pathomolecular classication followed the study of genotype/phenotype correlations which led to the identification of immunohistochemical data characteristic of each subgroup. Immunohistochemical characteristics described on resected specimen are suitable on biopies of these tumors, facilitating their diagnosis and therefore allowing a better management of the patients. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：439 / 447
页数：9
相关论文
共 50 条
  • [21] Hepatocellular Benign Tumors-From Molecular Classification to Personalized Clinical Care
    Nault, Jean-Charles
    Bioulac-Sage, Paulette
    Zucman-Rossi, Jessica
    GASTROENTEROLOGY, 2013, 144 (05) : 888 - 902
  • [22] Diagnosis of soft tissue tumors using immunohistochemistry as a surrogate for recurrent fusion oncoproteins
    Black, Margaret A.
    Charville, Gregory W.
    SEMINARS IN DIAGNOSTIC PATHOLOGY, 2022, 39 (01) : 38 - 47
  • [23] Tissue Biomarkers in Hepatocellular Tumors: Which, When, and How
    Di Tommaso, Luca
    Roncalli, Massimo
    FRONTIERS IN MEDICINE, 2017, 4
  • [24] Benign tumors of the liver:: diagnosis and therapeutic implications
    Péluchon, P
    Laurent, C
    Saric, J
    JOURNAL DE CHIRURGIE, 2001, 138 (05): : 261 - 269
  • [25] Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma
    Joseph, Nancy M.
    Ferrell, Linda D.
    Jain, Dhanpat
    Torbenson, Michael S.
    Wu, Tsung-Teh
    Yeh, Matthew M.
    Kakar, Sanjay
    MODERN PATHOLOGY, 2014, 27 (01) : 62 - 72
  • [26] Benign and malignant Conjunctival Tumors in Diagnosis and Therapy
    Westekemper, Henrike
    Manthey, Anke
    Bechrakis, Nikolaos
    KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE, 2020, 237 (09) : 1143 - 1157
  • [27] Immunohistochemistry in the Diagnosis and Classification of Breast Tumors
    Sun, Hongxia
    Ding, Qingqing
    Sahin, Aysegul A.
    ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2023, 147 (10) : 1119 - 1132
  • [28] Pathologic Diagnosis of Early Hepatocellular Carcinoma: A Report of the International Consensus Group for Hepatocellular Neoplasia
    Kojiro, Masamichi
    Wanless, Ian R.
    Alves, Venancio
    Badve, Sunil
    Bala-baud, Charles
    Bedosa, Pierre
    Bhathal, Prithi
    Bioulac-Sage, Paulette
    Brunt, Elizabeth M.
    Burt, Alastair D.
    Craig, John R.
    Dhillon, Amar
    Ferrell, Linda
    Geller, Stephen A.
    Goodman, Zackary D.
    Gouw, Annette S. H.
    Guido, Maria
    Guindi, Maha
    Hytiroglou, Prodromos
    Kage, Masayoshi
    Kondo, Fukuo
    Kudo, Masutoshi
    Lauwers, Gregory Y.
    Nakano, Masayuki
    Paradis, Valerie
    Park, Young-Nyun
    Quaglia, Alberto
    Roncalli, Massimo
    Roskams, Tania
    Ruebner, Boris
    Sakamoto, Michiie
    Sax-ena, Romil
    Theise, Neil D.
    Thung, Swan
    Toniakos, Dina
    HEPATOLOGY, 2009, 49 (02) : 658 - 664
  • [29] Benign hepatocellular tumors, morphological and molecular data: a new classification
    Bioulac-Sage, Paulette
    ACTA ENDOSCOPICA, 2006, 36 (03) : 335 - 342
  • [30] Novel uses of immunohistochemistry in the diagnosis and classification of soft tissue tumors
    Hornick, Jason L.
    MODERN PATHOLOGY, 2014, 27 : S47 - S63
12345