Carbonates: eco-friendly solvents for palladium-catalysed direct arylation of heteroaromatics

被引：99
作者：
Dong, Jia Jia [1 ]
Roger, Julien [1 ]
Verrier, Cecile [2 ,3 ]
Martin, Thibaut [2 ,3 ]
Le Goff, Ronan [1 ]
Hoarau, Christophe [2 ,3 ]
Doucet, Henri [1 ]
机构：
[1] Univ Rennes 1 Catalyse & Organometall, CNRS, Inst Sci Chim Rennes, UMR 6226, F-35042 Rennes, France
[2] Univ Rouen, F-76131 Mont St Aignan, France
[3] INSA, CNRS, Inst Chim Organ Fine IRCOF Associee, UMR 6014, F-76131 Mont St Aignan, France
来源：
GREEN CHEMISTRY | 2010年 / 12卷 / 11期
关键词：
DIRECT C-2 ARYLATION; INCLUDING FREE (NH)-IMIDAZOLE; CROSS-COUPLING REACTIONS; C-H FUNCTIONALIZATION; DIMETHYL CARBONATE; ROOM-TEMPERATURE; ARYL HALIDES; REGIOSELECTIVE SYNTHESIS; ALTERNATIVE SOLVENTS; PROPYLENE CARBONATE;
D O I：
10.1039/c0gc00229a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The palladium-catalysed direct 2-, 4- or 5-arylation of a wide range of heteroaromatics with aryl halides proceed in moderate to good yields using the eco-friendly solvents carbonates. The best yields were obtained using benzoxazole or thiazole derivatives. The arylation of furan, thiophene, pyrrole, imidazole or isoxazole derivatives was found to require a more elevated reaction temperature.
引用
收藏
页码：2053 / 2063
页数：11
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