Heatmapper: web-enabled heat mapping for all

被引:1670
作者
Babicki, Sasha [1 ]
Arndt, David [1 ]
Marcu, Ana [1 ]
Liang, Yongjie [1 ]
Grant, Jason R. [1 ]
Maciejewski, Adam [2 ]
Wishart, David S. [1 ,2 ,3 ]
机构
[1] Univ Alberta, Dept Comp Sci, Edmonton, AB T6G 2E8, Canada
[2] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada
[3] Natl Inst Nanotechnol, 11421 Saskatchewan Dr, Edmonton, AB T6G 2M9, Canada
基金
加拿大健康研究院;
关键词
MICROARRAY; VISUALIZATION;
D O I
10.1093/nar/gkw419
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Heatmapper is a freely available web server that allows users to interactively visualize their data in the form of heat maps through an easy-to-use graphical interface. Unlike existing non-commercial heat map packages, which either lack graphical interfaces or are specialized for only one or two kinds of heat maps, Heatmapper is a versatile tool that allows users to easily create a wide variety of heat maps for many different data types and applications. More specifically, Heatmapper allows users to generate, cluster and visualize: (i) expression-based heat maps from transcriptomic, proteomic and metabolomic experiments; (ii) pairwise distance maps; (iii) correlation maps; (iv) image overlay heat maps; (v) latitude and longitude heat maps and (vi) geopolitical (choropleth) heat maps. Heatmapper offers a number of simple and intuitive customization options for facile adjustments to each heat map's appearance and plotting parameters. Heatmapper also allows users to interactively explore their numeric data values by hovering their cursor over each heat map cell, or by using a searchable/sortable data table view. Heat map data can be easily uploaded to Heatmapper in text, Excel or tab delimited formatted tables and the resulting heat map images can be easily downloaded in common formats including PNG, JPG and PDF. Heatmapper is designed to appeal to a wide range of users, including molecular biologists, structural biologists, microbiologists, epidemiologists, environmental scientists, agriculture/forestry scientists, fish and wildlife biologists, climatologists, geologists, educators and students. Heatmapper is available at http://www.heatmapper.ca.
引用
收藏
页码:W147 / W153
页数:7
相关论文
共 21 条
[1]   MeV+R: using MeV as a graphical user interface for Bioconductor applications in microarray analysis [J].
Chu, Vu T. ;
Gottardo, Raphael ;
Raftery, Adrian E. ;
Bumgarner, Roger E. ;
Yeung, Ka Yee .
GENOME BIOLOGY, 2008, 9 (07)
[2]   Open source clustering software [J].
de Hoon, MJL ;
Imoto, S ;
Nolan, J ;
Miyano, S .
BIOINFORMATICS, 2004, 20 (09) :1453-1454
[3]   MatrixPlot:: visualizing sequence constraints [J].
Gorodkin, J ;
Stærfeldt, HH ;
Lund, O ;
Brunak, S .
BIOINFORMATICS, 1999, 15 (09) :769-770
[4]   HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline [J].
Khomtchouk, Bohdan B. ;
Van Booven, Derek J. ;
Wahlestedt, Claes .
SOURCE CODE FOR BIOLOGY AND MEDICINE, 2014, 9 (01)
[5]   Pathway analysis of coronary atherosclerosis [J].
King, JY ;
Ferrara, R ;
Tabibiazar, R ;
Spin, JM ;
Chen, MM ;
Kuchinsky, A ;
Vailaya, A ;
Kincaid, R ;
Tsalenko, A ;
Deng, DXF ;
Connolly, A ;
Zhang, P ;
Yang, E ;
Watt, C ;
Yakhini, Z ;
Ben-Dor, A ;
Adler, A ;
Bruhn, L ;
Tsao, P ;
Quertermous, T ;
Ashley, EA .
PHYSIOLOGICAL GENOMICS, 2005, 23 (01) :103-118
[6]  
Kloczkowski Andrzej, 2009, Journal of Structural and Functional Genomics, V10, P67, DOI 10.1007/s10969-009-9062-2
[7]  
LAWSON R, 1956, Can Med Assoc J, V75, P309
[8]   The microarray explorer tool for data mining of cDNA microarrays: application for the mammary gland [J].
Lemkin, PF ;
Thornwall, GC ;
Walton, KD ;
Hennighausen, L .
NUCLEIC ACIDS RESEARCH, 2000, 28 (22) :4452-4459
[9]   COLOMBOS v3.0: leveraging gene expression compendia for cross- species analyses [J].
Moretto, Marco ;
Sonego, Paolo ;
Dierckxsens, Nicolas ;
Brilli, Matteo ;
Bianco, Luca ;
Ledezma-Tejeida, Daniela ;
Gama-Castro, Socorro ;
Galardini, Marco ;
Romualdi, Chiara ;
Laukens', Kris ;
Collado-Vides, Julio ;
Meysman, Pieter ;
Engelen, Kristof .
NUCLEIC ACIDS RESEARCH, 2016, 44 (D1) :D620-D623
[10]   Gitools: Analysis and Visualisation of Genomic Data Using Interactive Heat-Maps [J].
Perez-Llamas, Christian ;
Lopez-Bigas, Nuria .
PLOS ONE, 2011, 6 (05)