Characterization of chitosan-lysine surfactant bioactive coating on silicone substrate

被引：16

作者：

Ajdnik, Urban ^{[1
]}

Finsgar, Matjaz ^{[2
]}

Zemljic, Lidija Fras ^{[1
]}

机构：

[1] Univ Maribor, Inst Engn Mat & Design, Fac Mech Engn, Smetanova Ul 17, SLO-2000 Maribor, Slovenia

[2] Univ Maribor, Fac Chem & Chem Engn, Smetanova Ul 17, SLO-2000 Maribor, Slovenia

来源：

CARBOHYDRATE POLYMERS | 2020年 / 232卷

关键词：

Chitosan; Lysine surfactant; Polydimethylsiloxane; Bioactive coating; QCM-D; Surface analysis; ETHYL(HYDROXYETHYL) CELLULOSE; CATIONIC SURFACTANT; HYALURONIC-ACID; CROSS-LINKING; NANOPARTICLES; POLYDIMETHYLSILOXANE; BIOPOLYMERS; DOXORUBICIN; HEMOLYSIS; MIXTURES;

D O I：

10.1016/j.carbpol.2019.115817

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chitosan (Chi) and anionic surfactant derived from lysine (77KS) were used to prepare a novel bioactive coating and as a drug delivery system for amoxicillin (AMOX) on a model polydimethylsiloxane (PDMS) surface. The bioactive coating was formulated as polyelectrolyte-surfactant complex (PESC). Aggregation behaviour between the cationic Chi and oppositely charged 77KS in bulk was analysed using turbidity and.-potential measurement. Furthermore, the adsorption and stability of the formulations were evaluated using quartz crystal microbalance with dissipation (QCM-D). The effect of the ionic strength and of the ultraviolet/ozone (UVO) activation of the PDMS films on the adsorption behaviour of the PESC complex was also examined. QCM-D monitoring showed stable adsorption of bare and AMOX-loaded complex on non-activated PDMS films, while the coating on UVO-activated PDMS samples desorbed after the rinsing step. Finally, X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry confirmed successful and homogenously distributed compounds.

引用

页数：10

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