Luteolin suppresses growth and migration of human lung cancer cells

被引：37

作者：

Zhao, Yunxue ^{[2
]}

Yang, Guotao ^{[1
]}

Ren, Dongmei ^{[3
]}

Zhang, Xiumei ^{[2
]}

Yin, Qiuwei ^{[1
]}

Sun, Xuefei ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Jinan 250012, Peoples R China

[2] Shandong Univ, Dept Pharmacol, Sch Med, Jinan 250012, Peoples R China

[3] Shandong Univ, Dept Nat Product Chem, Sch Pharmaceut Sci, Jinan 250012, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2011年 / 38卷 / 02期

关键词：

Luteolin; Lung cancer; Cell cycle; Apoptosis; Migration; Stress fiber; 1-DEOXYNOJIRIMYCIN;

D O I：

10.1007/s11033-010-0208-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Luteolin, 3',4',5,7-tetrahydroxyflavone, has been shown to possess antioxidant, anti-inflammation and anti-cancer properties. However, its role in lung cancer remains poorly understood. Here we examined the anti-tumorigenic role of luteolin in a commonly used lung cancer cell line. Luteolin inhibited the growth of A549 cells by inducing G1 phase cell cycle arrest and apoptosis. Furthermore, stress fiber assembly and cell migration in A549 cells was markedly suppressed by luteolin.

引用

页码：1115 / 1119

页数：5

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