Relationship between proteinuria and optical coherence tomographic features of the chorioretina in patients with pre-eclampsia

被引:6
作者
Shim, Kyu Young [1 ]
Bae, Jin Gon [2 ]
Lee, Jae Kyoung [1 ]
Kim, Yu Cheol [1 ]
机构
[1] Keimyung Univ, Dept Ophthalmol, Sch Med, Daegu, South Korea
[2] Keimyung Univ, Dept Obstet, Sch Med, Daegu, South Korea
关键词
CHOROIDAL VASCULARITY INDEX; FOVEAL AVASCULAR ZONE; PHYSIOLOGICAL-CHANGES; NORMAL-PREGNANCY; THICKNESS; WOMEN; HYPERTENSION; ANGIOGRAPHY; DISEASE; EYES;
D O I
10.1371/journal.pone.0251933
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This retrospective study aimed to evaluate the correlation between ophthalmologic factors and proteinuria in patients with pre-eclampsia using swept-source optical coherence tomography (OCT) and OCT angiography. In total, 61 pregnant patients diagnosed with pre-eclampsia were recruited during their hospital stay. The authors investigated the relationship between urine protein-creatinine ratio (PCR) and chorioretinal measurements including choroidal thickness (CT), choroidal vascularity index (CVI), foveal avascular zone (FAZ), vascular density (VD), ganglion cell layer+ (GCL+) and GCL++. The associations between mean arterial pressure (MAP) and ophthalmologic factors were also evaluated. Central subfield CT of the right eye (p = 0.031) and paracentral CT of both eyes were related to higher PCR (>= 1.35 mg/mg). A significant association with PCR after logarithm transformation was noted (r = 0.284, p = 0.026). Retinal measurements (FAZ, VD, GCL+ and GCL++) and CVI were not related with PCR. There was a positive association between MAP and PCR after logarithm transformation (r = 0.296, p = 0.021); however, chorioretinal factors were not related with MAP. In pregnant women with pre-eclampsia, CT using OCT is a novel factor that is correlated with PCR. Ocular structural alteration in patients with pre-eclampsia may be one of systemic vascular changes caused by pre-eclampsia rather than hypertension.
引用
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页数:12
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