Tumor-suppressive activity of retinoic acid receptor-β in cancer

被引：102

作者：

Xu, Xiao-Chun ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Clin Canc Prevent, Unit 1360, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2007年 / 253卷 / 01期

关键词：

retinoids; RAR-beta(2); RAR-beta(4); biomarker; methylation; tumorigenesis;

D O I：

10.1016/j.canlet.2006.11.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Retinoids, a group of structural and functional analogs of vitamin A, are known to regulate a large number of essential biological processes and to suppress carcinogenesis. The effects of retinoids are mainly mediated by nuclear retinoid receptors, which include retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Each receptor has three subtypes (alpha, beta, and gamma) and each subtype has different isoforms. Retinoic acid receptor-beta (RAR-beta) has four isoforms that have different affinities to retinoids and different biological functions. Loss of expression of RAR-beta(2) during cancer development is associated with tumorigenesis and retinoid resistance; induction of its expression, on the other hand, can suppress carcinogenesis. Expression of another isoform, RAR-beta(4), is increased in various types of cancer. RAR-beta(4) transgenic mice develop hyperplasia and neoplasia in various tissues, and induction of RAR-beta(4) expression increases the growth of tumor cells that do not express RAR-beta(2). Future studies will focus on molecular pathways involving RAR-beta(2) and the role of RAR-beta(4) in cancer development. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：14 / 24

页数：11

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