Experimental posttraumatic Bacillus cereus endophthalmitis in a swine model - Efficacy of intravitreal ciprofloxacin, vancomycin, and imipenem

被引:12
作者
Alfaro, DV
Hudson, SJ
Steele, JJ
Bevin, AA
Mines, M
Laughlin, RM
Schoderbek, RJ
机构
[1] Uniformed Services, University of the Health Sciences, Bethesda, MD
[2] Uniformed Services University, Bethesda, MD 20814-4799
来源
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 1996年 / 16卷 / 04期
关键词
Bacillus cereus; ciprofloxacin; endophthalmitis; imipenem; swine; trauma; vancomycin;
D O I
10.1097/00006982-199616040-00007
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: The authors compare the intravitreal efficacy of ciprofloxacin, vancomycin and imipenem, in treating experimental Bacillus cereus endophthalmitis. Methods: Thirty-three Yorkshire pigs received a surgically induced injury to the right eye, which was then repaired and injected with 8400 colony forming units of live B. cereus. Nine pigs received no therapy and served as a natural history group. Twenty-four other pigs then were randomized into a treatment group with ciprofloxacin (n = 6), vancomycin (n = 6), imipenem (n = 6), or normal saline (n = 6). Eyes were examined clinically 1, 2, 3, 4, 5, 6, 8, 12, and 24 hours after inoculation. After 24 hours, the eyes were enucleated for histologic study. Results: Experimental disease was characterized by an aggressively developing endophthalmitis, with retinitis and vitritis developing at 4 hours. Histologic examination showed vitreous abscess and retinal necrosis. Both vancomycin- and imipenem-treated groups had less inflammation and tissue destruction than control animals, based on the Wilcoxon rank sum test (P < 0.05). Ciprofloxacin-treated animals showed significantly more intraocular destruction and were indistinguishable from controls. Conclusion: Vancomycin and imipenem appear to limit inflammation and tissue destruction when given early in the course of experimental posttraumatic endophthalmitis caused by B. cereus. Results with ciprofloxacin are less conclusive and warrant further investigation.
引用
收藏
页码:317 / 323
页数:7
相关论文
共 27 条
[1]  
AFFELDT JC, 1987, OPHTHALMOLOGY, V94, P407
[2]   POSTTRAUMATIC ENDOPHTHALMITIS - CAUSATIVE ORGANISMS, TREATMENT, AND PREVENTION [J].
ALFARO, DV ;
ROTH, D ;
LIGGETT, PE .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 1994, 14 (03) :206-211
[3]   PHARMACOKINETICS OF NEWER CEPHALOSPORINS AFTER SUBCONJUNCTIVAL AND INTRAVITREAL INJECTION IN RABBITS [J].
BARZA, M ;
LYNCH, E ;
BAUM, JL .
ARCHIVES OF OPHTHALMOLOGY, 1993, 111 (01) :121-125
[4]  
BRINTON GS, 1984, ARCH OPHTHALMOL-CHIC, V102, P547
[5]   TOXICITY OF INTRAVITREOUS CEFTAZIDIME IN PRIMATE RETINA [J].
CAMPOCHIARO, PA ;
GREEN, WR .
ARCHIVES OF OPHTHALMOLOGY, 1992, 110 (11) :1625-1629
[6]  
DERRICK RJ, 1987, ANN OPHTHALMOL, V19, P338
[7]   EMPIRIC TREATMENT OF ENDOPHTHALMITIS - ARE AMINOGLYCOSIDES NECESSARY [J].
DONAHUE, SP ;
KOWALSKI, RP ;
ELLER, AW ;
DEVARO, JM ;
JEWART, BH .
ARCHIVES OF OPHTHALMOLOGY, 1994, 112 (01) :45-47
[8]  
ELBABA FZ, 1992, OPHTHALMOLOGY, V99, P483
[9]   ENDOPHTHALMITIS THERAPY - CHANGING ANTIBIOTIC-SENSITIVITY PATTERNS AND CURRENT THERAPEUTIC RECOMMENDATIONS [J].
FLYNN, HW ;
PULIDO, JS ;
PFLUGFELDER, SC ;
DAVIS, JL ;
CULBERTSON, WW ;
ROUSSEL, TJ ;
MILLER, D .
ARCHIVES OF OPHTHALMOLOGY, 1991, 109 (02) :175-176
[10]  
Forster R K, 1992, Trans Am Ophthalmol Soc, V90, P505