Changes in Ghrelin Levels Following Bariatric Surgery: Review of the Literature

被引:63
作者
Tymitz, Kevin [2 ]
Engel, Amy [1 ]
McDonough, Sarah [1 ]
Hendy, Mary Pat [1 ]
Kerlakian, George [2 ]
机构
[1] Good Samaritan Hosp, Inst Res & Educ, Cincinnati, OH 45220 USA
[2] Good Samaritan Hosp, Dept Surg, Cincinnati, OH 45220 USA
关键词
Obesity; Roux-en-Y gastric bypass; Adjustable gastric band; Sleeve gastrectomy; Biliopancreatic diversion-pancreatic switch; Bariatric surgery; Weight loss; Ghrelin; Type II diabetes; GASTRIC BYPASS-SURGERY; PEPTIDE-YY LEVELS; MORBIDLY OBESE-PATIENTS; PLASMA GHRELIN; WEIGHT-LOSS; SLEEVE GASTRECTOMY; BILIOPANCREATIC DIVERSION; GROWTH-HORMONE; BODY-WEIGHT; ADIPONECTIN;
D O I
10.1007/s11695-010-0311-z
中图分类号
R61 [外科手术学];
学科分类号
摘要
Obesity is a severe health issue that is a global epidemic. Bariatric surgery is an accepted, popular, and effective therapy for weight loss. Ghrelin, a peptide secreted primarily by the fundus cells of the stomach, has been found to impact body weight by its influence on appetite. Although numerous studies have investigated serum ghrelin levels following bariatric surgery, there is no solid agreement yet as to the direction or magnitude of its change, or even its impact on weight loss. Some studies have found an increase in ghrelin, some have found a decrease, and others have found no change in ghrelin following bariatric surgery. The purpose of this review was to establish the impact of ghrelin changes following bariatric surgery.
引用
收藏
页码:125 / 130
页数:6
相关论文
共 33 条
[1]   Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety [J].
Borg, CM ;
le Roux, CW ;
Ghatei, MA ;
Bloom, SR ;
Patel, AG ;
Aylwin, SJB .
BRITISH JOURNAL OF SURGERY, 2006, 93 (02) :210-215
[2]   Peptide YY levels are elevated after gastric bypass surgery [J].
Chan, Jean L. ;
Mun, Edward C. ;
Stoyneva, Violeta ;
Mantzoros, Christos S. ;
Goldfine, Allison B. .
OBESITY, 2006, 14 (02) :194-198
[3]   Is ghrelin the culprit for weight loss gastric bypass surgery? A negative answer [J].
Couce, Marta E. ;
Cottam, Daniel ;
Esplen, James ;
Schauer, Phillip ;
Burguera, Bartolome .
OBESITY SURGERY, 2006, 16 (07) :870-878
[4]   A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans [J].
Cummings, DE ;
Purnell, JQ ;
Frayo, RS ;
Schmidova, K ;
Wisse, BE ;
Weigle, DS .
DIABETES, 2001, 50 (08) :1714-1719
[5]   Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. [J].
Cummings, DE ;
Weigle, DS ;
Frayo, RS ;
Breen, PA ;
Ma, MK ;
Dellinger, EP ;
Purnell, JQ .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (21) :1623-1630
[6]   Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects [J].
Faraj, M ;
Havel, PJ ;
Phélis, S ;
Blank, D ;
Sniderman, AD ;
Cianflone, K .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (04) :1594-1602
[7]   Cause-specific excess deaths associated with underweight, overweight, and obesity [J].
Flegal, Katherine M. ;
Graubard, Barry I. ;
Williamson, David F. ;
Gail, Mitchell H. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (17) :2028-2037
[8]   Excess deaths associated with underweight, overweight, and obesity [J].
Flegal, KM ;
Graubard, BI ;
Williamson, DF ;
Gail, MH .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (15) :1861-1867
[9]   Fasting plasma ghrelin concentrations 6 months after gastric bypass are not determined by weight loss or changes in insulinemia [J].
Frühbeck, G ;
Rotellar, F ;
Hernández-Lizoain, JL ;
Gil, MJ ;
Gómez-Ambrosi, J ;
Salvador, J ;
Cienfuegos, JA .
OBESITY SURGERY, 2004, 14 (09) :1208-1215
[10]   Ghrelin: a gut-brain hormone: Effect of gastric bypass surgery [J].
Geloneze, B ;
Tambascia, MA ;
Pilla, VF ;
Geloneze, SR ;
Repetto, EM ;
Pareja, JC .
OBESITY SURGERY, 2003, 13 (01) :17-22