Development and Function of the Adrenal Zona Reticularis in Rats Prenatally and Postnatally Exposed to the Endocrine Disruptor DDT

被引：0
|
作者：
Yaglova, N. V. [1 ]
Obernikhin, S. S. [1 ]
Nazimova, S. V. [1 ]
Timokhina, E. P. [1 ]
Tsomartova, D. A. [1 ]
Yaglov, V. V. [1 ]
机构：
[1] Res Inst Human Morphol, Moscow 117418, Russia
来源：
BIOLOGY BULLETIN | 2022年 / 49卷 / 03期
关键词：
adrenal; zona reticularis; development; Oct4; Shh; PRH; endocrine disruptor; DDT; SONIC HEDGEHOG; DICHLORODIPHENYLTRICHLOROETHANE DDT; TARGETED DISRUPTION; CATENIN; STEM; MAINTENANCE; CHEMICALS; MEMBRANE; BIOLOGY; CORTEX;
D O I：
10.1134/S1062359022030177
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The parameters of postnatal development and its transcriptional control, as well as functioning of the adrenal zona reticularis, in rats prenatally and postnatally exposed to the endocrine disruptor dichlorodiphenyltrichloroetane (DDT) were studied. It was found that developmental exposure to the endocrine disruptor affects both the rates of growth and the functional maturation of the zona reticularis. The investigation revealed some mechanisms of the dysmorphogenetic action of DDT, which consisted in altered expression of transcription factors PRH, Oct4, and the Shh ligand and activation of canonical Wnt signaling. The data obtained also demonstrate the important role of pluripotency factors in ensuring normal growth and physiological regeneration of the zona reticularis.
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收藏
页码：125 / 132
页数：8
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