Lipase-catalyzed selective benzoylation of 1,2-diols with vinyl benzoate in organic solvents

被引：20

作者：

Ciuffreda, P ^{[1
]}

Alessandrini, L ^{[1
]}

Terraneo, G ^{[1
]}

Santaniello, E ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Sci Preclin, LITA Vialba, I-20157 Milan, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 20期

关键词：

D O I：

10.1016/j.tetasy.2003.07.003

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lipases from Mucor miehei (MML) and Candida antarctica (CAL) are able to catalyze the benzoylation of the primary hydroxy group of 1.2-diols with vinyl benzoate in organic solvents. We have studied the MML-catalyzed benzoylation that proceeds with high regioselectivity and moderate enantioselectivity, whereas in the dibenzoylation reaction activity of MML and stereoselectivity of the enzymatic process is strongly influenced by steric factors. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：3197 / 3201

页数：5

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