BACE1 is the major β-secretase for generation of Aβ peptides by neurons

被引：921

作者：

Cai, HB

Wang, YS

McCarthy, D

Wen, HJ

Borchelt, DR

Price, DL

Wong, PC ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Program Cellular & Mol Med, Baltimore, MD 21205 USA

[6] Ciphergen Biosyst, Fremont, CA 94555 USA

来源：

NATURE NEUROSCIENCE | 2001年 / 4卷 / 03期

关键词：

D O I：

10.1038/85064

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[No abstract available]

引用

页码：233 / 234

页数：2

共 15 条

[1] Expression analysis of BACE2 in brain and peripheral tissues [J].

Bennett, BD ;

Babu-Khan, S ;

Loeloff, R ;

Louis, JC ;

Curran, E ;

Citron, M ;

Vassar, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (27) :20647-20651

[2]

Buxbaum JD, 1998, J NEUROSCI, V18, P9629

[3] Maturation and pro-peptide cleavage of β-secretase [J].

Capell, A ;

Steiner, H ;

Willem, M ;

Kaiser, H ;

Meyer, C ;

Walter, J ;

Lammich, S ;

Multhaup, G ;

Haass, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (40) :30849-30854

[4] BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein [J].

Farzan, M ;

Schnitzler, CE ;

Vasilieva, N ;

Leung, D ;

Choe, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (17) :9712-9717

[5]

Gouras GK, 1998, J NEUROCHEM, V71, P1920

[6] Characterization of Alzheimer's β-secretase protein BACE -: A pepsin family member with unusual properties [J].

Haniu, M ;

Denis, P ;

Young, Y ;

Mendiaz, EA ;

Fuller, J ;

Hui, JO ;

Bennett, BD ;

Kahn, S ;

Ross, S ;

Burgess, T ;

Katta, V ;

Rogers, G ;

Vassar, R ;

Citron, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (28) :21099-21106

[7] Structure of the protease domain of memapsin 2 (β-secretase) complexed with inhibitor [J].

Hong, L ;

Koelsch, G ;

Lin, XL ;

Wu, SL ;

Terzyan, S ;

Ghosh, AK ;

Zhang, XC ;

Tang, J .

SCIENCE, 2000, 290 (5489) :150-153

[8] RELATIVE ABUNDANCE OF ALZHEIMER A-BETA AMYLOID PEPTIDE VARIANTS IN ALZHEIMER-DISEASE AND NORMAL AGING [J].

NASLUND, J ;

SCHIERHORN, A ;

HELLMAN, U ;

LANNFELT, L ;

ROSES, AD ;

TJERNBERG, LO ;

SILBERRING, J ;

GANDY, SE ;

WINBLAD, B ;

GREENGARD, P ;

NORDSTEDT, C ;

TERENIUS, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (18) :8378-8382

[9] AMINO-TERMINAL DELETIONS ENHANCE AGGREGATION OF BETA-AMYLOID PEPTIDES IN-VITRO [J].

PIKE, CJ ;

OVERMAN, MJ ;

COTMAN, CW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (41) :23895-23898

[10] Mutant genes in familial Alzheimer's disease and transgenic models [J].

Price, DL ;

Sisodia, SS .

ANNUAL REVIEW OF NEUROSCIENCE, 1998, 21 :479-505

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