Calretinin Expression in the Mammalian Neocortex: A Review

被引:110
作者
Barinka, F. [1 ]
Druga, R. [1 ,2 ,3 ]
机构
[1] Charles Univ Prague, Dept Anat, Fac Med 2, U Nemocnice 3, Prague 12800, Czech Republic
[2] Charles Univ Prague, Dept Anat, Fac Med 1, Prague 12800, Czech Republic
[3] Acad Sci Czech Republ, Inst Physiol, Dept Dev Epileptol, Prague, Czech Republic
关键词
Calcium-binding proteins; Interneurons; Inhibition; Neuroprotection; Neurovascular coupling; CALCIUM-BINDING PROTEINS; LOCAL-CIRCUIT NEURONS; MONKEY PREFRONTAL CORTEX; TERM POTENTIATION INDUCTION; NITRIC-OXIDE SYNTHASE; HUMAN TEMPORAL CORTEX; IMMUNOREACTIVE NEURONS; CALBINDIN D-28K; GABAERGIC NEURONS; SYNAPTIC CONNECTIONS;
D O I
10.33549/physiolres.931930
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
In the mammalian neocortex, the calcium-binding protein calretinin is expressed in a subset of cortical interneurons. In the recent years, research on interneurons is one of the most rapidly growing fields in neuroscience. This review summarizes the actual knowledge of the functions of calretinin in neuronal homeostasis and particularly of the distribution, connectivity and physiological properties of calretinin expressing interneurons in the neocortex of rodents and primates, including humans. The possible neuroprotective role of calretinin and the presumed "resistance" of calretinin-expressing interneurons to various pathological processes are also discussed.
引用
收藏
页码:665 / 677
页数:13
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