Serum levels of IL-6, IL-8, and IL-10 are indicators of prognosis in pancreatic cancer

被引：91
作者：
Feng, Lanyun [1 ,2 ]
Qi, Qi [1 ,2 ]
Wang, Peng [1 ,2 ]
Chen, Hao [1 ,2 ]
Chen, Zhen [1 ,2 ]
Meng, Zhiqiang [1 ,2 ]
Liu, Luming [1 ,2 ]
机构：
[1] Fudan Univ, Shanghai Canc Ctr, Dept Integrat Oncol, Shanghai, Peoples R China
[2] Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2018年 / 46卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Pancreatic cancer; interleukin; IL-6; IL-8; IL-10; prediction marker; HEPATOCELLULAR-CARCINOMA; POOR-PROGNOSIS; EXPRESSION; INTERLEUKIN-8; CYTOKINES; GROWTH; CELLS; CXCL8/IL-8; ACTIVATION; IL-1-BETA;
D O I：
10.1177/0300060518800588
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective Early detection and prognosis prediction are critical to improve patient survival in pancreatic cancer. This study aimed to investigate whether interleukins could serve as indicators of prognosis in pancreatic cancer. Methods Sixty-eight patients with pancreatic cancer were enrolled in the study during the period between 2012 and 2014. The serum levels of a broad spectrum of interleukins in these patients were determined, including IL-1 beta, IL-2, IL-6, IL-8, IL-10, IL-13, IL-15, and IL-23. Results IL-6, IL-8, and IL-10 showed significant positive correlations with each other. Moreover, high levels of serum IL-6, IL-8, and IL-10 were independently strongly associated with poor survival of patients with pancreatic cancer. Conclusions Our results suggest that serum levels of IL-6, IL-8, and IL-10 could be useful markers for prediction of prognosis in patients with pancreatic cancer.
引用
收藏
页码：5228 / 5236
页数：9
相关论文
共 43 条
[1]   Role of interleukin-8 in tumor growth and metastasis of human melanoma [J].
Bar-Eli, M .
PATHOBIOLOGY, 1999, 67 (01) :12-18
[2]   Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival [J].
Bellone, G ;
Smirne, C ;
Mauri, FA ;
Tonel, E ;
Carbone, A ;
Buffolino, A ;
Dughera, L ;
Robecchi, A ;
Pirisi, M ;
Emanuelli, G .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2006, 55 (06) :684-698
[3]   Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival [J].
Benoy, IH ;
Salgado, R ;
Van Dam, P ;
Geboers, K ;
Van Marck, E ;
Scharpé, S ;
Vermeulen, PB ;
Dirix, LY .
CLINICAL CANCER RESEARCH, 2004, 10 (21) :7157-7162
[4]   Pancreatitis and pancreatic cancer in two large pooled case-control studies [J].
Bracci, Paige M. ;
Wang, Furong ;
Hassan, Manal M. ;
Gupta, Samir ;
Li, Donghui ;
Holly, Elizabeth A. .
CANCER CAUSES & CONTROL, 2009, 20 (09) :1723-1731
[5]   Early Detection of Sporadic Pancreatic Cancer Summative Review [J].
Chari, Suresh T. ;
Kelly, Kimberly ;
Hollingsworth, Michael A. ;
Thayer, Sarah P. ;
Ahlquist, David A. ;
Andersen, Dana K. ;
Batra, Surinder K. ;
Brentnall, Teresa A. ;
Canto, Marcia ;
Cleeter, Deborah F. ;
Firpo, Matthew A. ;
Gambhir, Sanjiv Sam ;
Go, Vay Liang W. ;
Hines, O. Joe ;
Kenner, Barbara J. ;
Klimstra, David S. ;
Lerch, Markus M. ;
Levy, Michael J. ;
Maitra, Anirban ;
Mulvihill, Sean J. ;
Petersen, Gloria M. ;
Rhim, Andrew D. ;
Simeone, Diane M. ;
Srivastava, Sudhir ;
Tanaka, Masao ;
Vinik, Aaron I. ;
Wong, David .
PANCREAS, 2015, 44 (05) :693-712
[6]   The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases [J].
Chen, Lianyu ;
Fan, Jie ;
Chen, Hao ;
Meng, Zhiqiang ;
Chen, Zhen ;
Wang, Peng ;
Liu, Luming .
SCIENTIFIC REPORTS, 2014, 4
[7]   Interleukin-8, a promising predictor for prognosis of pancreatic cancer [J].
Chen, Ying ;
Shi, Min ;
Yu, Guan-Zhen ;
Qin, Xiao-Ran ;
Jin, Gang ;
Chen, Peng ;
Zhu, Ming-Hua .
WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (10) :1123-1129
[8]   Interleukin 10 expression is related to aggressiveness and poor prognosis of patients with thyroid cancer [J].
Cunha, Lucas Leite ;
Morari, Elaine Cristina ;
Nonogaki, Sueli ;
Marcello, Marjory Alana ;
Soares, Fernando Augusto ;
Vassallo, Jose ;
Ward, Laura Sterian .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2017, 66 (02) :141-148
[9]   Biomarker potential of IL-6 and VEGF-A in ascitic fluid of epithelial ovarian cancer patients [J].
Dalal, Venus ;
Kumar, Raman ;
Kumar, Sunesh ;
Sharma, Alpana ;
Kumar, Lalit ;
Sharma, Jai Bhagwan ;
Roy, Kallol Kumar ;
Singh, Neeta ;
Vanamail, Perumal .
CLINICA CHIMICA ACTA, 2018, 482 :27-32
[10]   T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine [J].
Dennis, Kristen L. ;
Saadalla, Abdulrahman ;
Blatner, Nichole R. ;
Wang, Shuya ;
Venkateswaran, Vysak ;
Gounari, Fotini ;
Cheroutre, Hilde ;
Weaver, Casey T. ;
Roers, Axel ;
Egilmez, Nejat K. ;
Khazaie, Khashayarsha .
CANCER IMMUNOLOGY RESEARCH, 2015, 3 (07) :806-814
12345