Palladium-catalyzed homocouplingr of aryl halides in the presence of fluoride

被引：46
|
作者：
Seganish, WM [1 ]
Mowery, ME [1 ]
Riggleman, S [1 ]
DeShong, P [1 ]
机构：
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
来源：
TETRAHEDRON | 2005年 / 61卷 / 08期
基金：
美国国家卫生研究院;
关键词：
tetrabutylammonium fluoride; aryl homocoupling; Ullmann coupling;
D O I：
10.1016/j.tet.2004.12.040
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This report describes the fluoride-mediated homocoupling of aryl iodides and bromides catalyzed by palladium(0). This coupling protocol is tolerant of electron-donating and electron-withdrawing substitutents on the aryl halide, as well as ortho substitution. Optimum reaction conditions entail 10 mol% Pd(dba)(2), 3 equiv of tetrabutyl ammonium fluoride (TBAF) in DMF at 90 degreesC. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2117 / 2121
页数：5
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