Characteristics of subjective cognitive decline associated with amyloid positivity

被引：35

作者：

Janssen, Olin ^{[1
]}

Jansen, Willemijn J. ^{[1
]}

Vos, Stephanie J. B. ^{[1
]}

Boada, Merce ^{[29
,30
]}

Parnetti, Lucilla ^{[12
]}

Gabryelewicz, Tomasz ^{[16
]}

Fladby, Tormod ^{[17
]}

Molinuevo, Jose Luis ^{[5
]}

Villeneuve, Sylvia ^{[39
]}

Hort, Jakub ^{[35
,36
,37
]}

Epelbaum, Stephane ^{[20
,21
]}

Lleo, Alberto ^{[38
]}

Engelborghs, Sebastiaan ^{[42
,43
]}

van der Flier, Wiesje M. ^{[2
]}

Landau, Susan ^{[31
]}

Popp, Julius ^{[40
,41
]}

Wallin, Anders ^{[13
,34
]}

Scheltens, Philip ^{[2
]}

Rikkert, Marcel Olde ^{[15
]}

Snyder, Peter J. ^{[18
,19
]}

Rowe, Chris ^{[22
]}

Chetelat, Gael ^{[32
]}

Ruiz, Agustin ^{[29
,30
]}

Marquie, Marta ^{[29
,30
]}

Chipi, Elena ^{[12
]}

Wolfsgruber, Steffen ^{[25
,26
]}

Heneka, Michael ^{[26
]}

Boecker, Henning ^{[27
]}

Peters, Oliver ^{[28
]}

Jarholm, Jonas ^{[17
]}

Rami, Lorena ^{[5
]}

Tort-Merino, Adria ^{[5
]}

Binette, Alexa Pichet ^{[39
]}

Poirier, Judes ^{[39
]}

Rosa-Neto, Pedro ^{[39
]}

Cerman, Jiri ^{[35
,36
,37
]}

Dubois, Bruno ^{[20
]}

Teichmann, Marc ^{[20
]}

Alcolea, Daniel ^{[38
]}

Fortea, Juan ^{[38
]}

Sanchez-Saudinos, M. Belen ^{[38
]}

Ebenau, Jarith ^{[2
]}

Pocnet, Cornelia ^{[41
]}

Eckerstrom, Marie ^{[34
]}

Thompson, Louisa ^{[18
,19
]}

Villemagne, Victor ^{[22
,23
]}

Buckley, Rachel ^{[8
,9
]}

Burnham, Samantha ^{[12
]}

Delarue, Marion ^{[32
]}

Freund-Levi, Yvonne ^{[3
]}

机构：

[1] Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands

[2] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

[3] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

[4] Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Lund, Sweden

[5] Hosp Clin Barcelona, August Pi & Sunyer Biomed Res Inst IDIBAPS, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain

[6] Aristotle Univ Thessaloniki, G Papanicolau Gen Hosp, Memory & Dementia Ctr, Dept Neurol 3, Thessaloniki, Greece

[7] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Alzheimer Precis Med AMP,GRC 21, Paris, France

[8] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

[9] Harvard Med Sch, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[10] Carol DAVILA Univ Med & Pharm, Bucharest, Romania

[11] Ana Aslan Int Fdn, Alzheimer Unit, Geriatr Gerontol & Old Age Psychiat, Memory Ctr & Longev Med, Bucharest, Romania

[12] Univ Perugia, Ctr Memory Disturbances, Dept Med & Surg, Sect Neurol,Lab Clin Neurochem, Perugia, Italy

[13] CSIRO Hlth & Biosecur, Parkville, Vic, Australia

[14] Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden

[15] Radboud Univ Nijmegen, Radboud Alzheimer Ctr, Dept Geriatr Med, Med Ctr, Nijmegen, Netherlands

[16] Polish Acad Sci, Mossakowski Med Res Ctr, Dept Neurodegenerat Disorders, Warsaw, Poland

[17] Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway

[18] Univ Oslo, Inst Clin Med, Oslo, Norway

[19] Univ Rhode Isl, Kingston, RI 02881 USA

[20] Hop Pitie Salpetiere, AP HP, Ctr Excellence Neurodegenerat Dis CoEN, Inst Memory & Alzheimers Dis IM2A,Dept Neurol, Paris, France

[21] Sorbonne Univ, Aramis Project Team, INRIA, Paris Brain Inst,Inst Cerveau ICM,INSERM, Paris, France

[22] Austin Hlth, Dept Mol Imaging & Therapy, Melbourne, Vic, Australia

[23] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[24] Univ Cologne, Dept Psychiat, Cologne, Germany

[25] Deutsch Zentrum Neurodegenerat Erkrankungen eV DZ, German Ctr Neurodegenerat Dis Clin Res, Zentrum Klin Forsch AG, Cologne, Germany

[26] Univ Hosp Bonn, Dept Neurodegenerat Dis & Psychiat, Bonn, Germany

[27] Univ Hosp Bonn, Dept Radiol, Funct Neuroimaging Grp, Bonn, Germany

[28] Charite Univ Med Berlin CBF, Klin Psychiat & Psychotherapie, Berlin, Germany

[29] Univ Int Catalunya Barcelona, Fac Med, Inst Catala Neurociencies Aplicades, Fundacio ACE, Barcelona, Spain

[30] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain

[31] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[32] INSERM, Inst Natl St & Rech Mdicale, Caen, France

[33] Univ Eastern Finland, Inst Clin Med, Neurol, Kuopio, Finland

[34] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Molndal, Sweden

[35] Charles Univ Prague, Fac Med 2, Dept Neurol, Prague, Czech Republic

[36] Motol Univ Hosp, Prague, Czech Republic

[37] St Annes Univ Hosp, Int Clin Res Ctr, Brno, Czech Republic

[38] Hosp Santa Creu & Sant Pau, Neurol Dept, Barcelona, Spain

[39] Ctr Studies Prevent Alzheimers Dis StOP AD Ctr, Montreal, PQ, Canada

[40] Univ Hosp Zurich, Dept Geriatr Psychiat Psychiat, Zurich, Switzerland

[41] Univ Hosp Lausanne, Old Age Psychiat, Lausanne, Switzerland

[42] Vrije Univ Brussel, VUB Brussels, Brussels, Belgium

[43] Univ Antwerp, Antwerp, Belgium

来源：

ALZHEIMERS & DEMENTIA | 2022年 / 18卷 / 10期

基金：

美国国家卫生研究院; 英国医学研究理事会; 欧盟地平线“2020”; 加拿大健康研究院;

关键词：

Alzheimer's disease; amyloid; cerebrospinal fluid; positron emission tomography; subjective cognitive decline; PRECLINICAL ALZHEIMERS-DISEASE; MEMORY COMPLAINTS; OLDER-ADULTS; DEMENTIA; POPULATION; RISK; COMMUNITY; PREVALENCE; DEPOSITION; SYMPTOMS;

D O I：

10.1002/alz.12512

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) epsilon 4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE epsilon 4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion Next to age, setting, and APOE epsilon 4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.

引用

页码：1832 / 1845

页数：14

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