Enantioselective Preparation of P-Chiral Phosphine Oxides

被引：59

作者：

Adams, Harry ^{[1
]}

Collins, Rebecca C. ^{[1
]}

Jones, Simon ^{[1
]}

Warner, Christopher J. A. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

CATALYTIC ASYMMETRIC DEPROTONATION; KINETIC RESOLUTION; STEREOGENIC COMPOUNDS; PHOSPHORUS-COMPOUNDS; LIGANDS; BORANES; ROUTE; ORGANOCATALYSTS; DIPHOSPHINES; AUXILIARIES;

D O I：

10.1021/ol202916j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient chiral auxiliary-based strategy for the asymmetric synthesis of P-chiral phosphine oxides in >98:2 er has been developed. The methodology involves the highly stereoselective formation of P-chiral oxazolidinones that then undergo displacement with a variety of Grignard reagents to prepare the desired phosphine oxides.

引用

页码：6576 / 6579

页数：4

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