Enantioselective Preparation of P-Chiral Phosphine Oxides

被引：59
|
作者：
Adams, Harry [1 ]
Collins, Rebecca C. [1 ]
Jones, Simon [1 ]
Warner, Christopher J. A. [1 ]
机构：
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 24期
基金：
英国工程与自然科学研究理事会;
关键词：
CATALYTIC ASYMMETRIC DEPROTONATION; KINETIC RESOLUTION; STEREOGENIC COMPOUNDS; PHOSPHORUS-COMPOUNDS; LIGANDS; BORANES; ROUTE; ORGANOCATALYSTS; DIPHOSPHINES; AUXILIARIES;
D O I：
10.1021/ol202916j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient chiral auxiliary-based strategy for the asymmetric synthesis of P-chiral phosphine oxides in >98:2 er has been developed. The methodology involves the highly stereoselective formation of P-chiral oxazolidinones that then undergo displacement with a variety of Grignard reagents to prepare the desired phosphine oxides.
引用
收藏
页码：6576 / 6579
页数：4
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