Pharmacotherapies in Geriatric Chronic Pain Management

被引：25
作者：
Marcum, Zachary A. [1 ]
Duncan, Nakia A. [2 ]
Makris, Una E. [3 ]
机构：
[1] Univ Washington, Sch Pharm, Dept Pharm, 1959 Northeast Pacific Ave,Box 357630, Seattle, WA 98195 USA
[2] Texas Tech Univ, Hlth Sci Ctr, Sch Pharm, 4500 South Lancaster St,Bldg 7,Room 215, Dallas, TX USA
[3] UT Southwestern Med Ctr, VA North Texas Hlth Care Syst, Dept Internal Med, Div Rheumat Dis, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
来源：
CLINICS IN GERIATRIC MEDICINE | 2016年 / 32卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Chronic pain; Medication; Older adults; Adverse drug events; Polypharmacy; LOW-BACK-PAIN; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; DULOXETINE VS. PREGABALIN; MUSCULOSKELETAL PAIN; OLDER-ADULTS; NEUROPATHIC PAIN; PRESCRIBING OPIOIDS; UNITED-STATES; POSTHERPETIC NEURALGIA; DIABETIC-NEUROPATHY;
D O I：
10.1016/j.cger.2016.06.007
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Pharmacologic management of chronic pain in older adults is one component of the multimodal, interdisciplinary management of this complex condition. In this article, we summarize several of the key barriers to effective pharmacologic management in older adults and review the existing (albeit limited) evidence for its effectiveness and safety, especially in a medically complex population with multimorbidity. This review covers topical formulations, acetaminophen, oral nonsteroidal antiinflammatory drugs, and adjuvant therapies. The article concludes with a suggested approach to managing chronic pain in the older patient, incorporating goals and expectations for treatment as well as careful monitoring of medication adjustments.
引用
收藏
页码：705 / 724
页数：20
相关论文
共 85 条
[1]   Guidance on the management of pain in older people [J].
Abdulla, Aza ;
Adams, Nicola ;
Bone, Margaret ;
Elliott, Alison M. ;
Gaffin, Jean ;
Jones, Derek ;
Knaggs, Roger ;
Martin, Denis ;
Sampson, Liz ;
Schofield, Pat .
AGE AND AGEING, 2013, 42 :I1-I57
[2]   Racial and Ethnic Disparities in Pain: Causes and Consequences of Unequal Care [J].
Anderson, Karen O. ;
Green, Carmen R. ;
Payne, Richard .
JOURNAL OF PAIN, 2009, 10 (12) :1187-1204
[3]  
Argoff Charles E, 2014, Am J Gastroenterol Suppl, V2, P3, DOI 10.1038/ajgsup.2014.3
[4]   Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis A Systematic Review and Network Meta-analysis [J].
Bannuru, Raveendhara R. ;
Schmid, Christopher H. ;
Kent, David M. ;
Vaysbrot, Elizaveta E. ;
Wong, John B. ;
McAlindon, Timothy E. .
ANNALS OF INTERNAL MEDICINE, 2015, 162 (01) :46-U189
[5]   Chronic pain in Australia: a prevalence study [J].
Blyth, FM ;
March, LM ;
Brnabic, AJM ;
Jorm, LR ;
Williamson, M ;
Cousins, MJ .
PAIN, 2001, 89 (2-3) :127-134
[6]   Randomized, Placebo-Controlled Comparison of Amitriptyline, Duloxetine, and Pregabalin in Patients With Chronic Diabetic Peripheral Neuropathic Pain [J].
Boyle, Julia ;
Eriksson, Malin E. V. ;
Gribble, Laura ;
Gouni, Ravi ;
Johnsen, Sigurd ;
Coppini, David V. ;
Kerr, David .
DIABETES CARE, 2012, 35 (12) :2451-2458
[7]  
Bril V, 2011, PM&R, V3, P345, DOI [10.1016/j.pmrj.2011.03.008, 10.1212/WNL.0b013e3182166ebe]
[8]   Musculoskeletal Pain and Incident Disability in Community-Dwelling Older Adults [J].
Buchman, Aron S. ;
Shah, Raj C. ;
Leurgans, Sue E. ;
Boyle, Patricia A. ;
Wilson, Robert S. ;
Bennett, David A. .
ARTHRITIS CARE & RESEARCH, 2010, 62 (09) :1287-1293
[9]   Age as a predicting factor in the therapy outcome of multidisciplinary treatment of patients with chronic low back pain - a prospective longitudinal clinical study in 405 patients [J].
Buchner, Matthias ;
Neubauer, Eva ;
Zahlten-Hinguranage, Anita ;
Schiltenwolf, Marcus .
CLINICAL RHEUMATOLOGY, 2007, 26 (03) :385-392
[10]  
DEAL CL, 1991, CLIN THER, V13, P383
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