Measuring biomarkers to assess the therapeutic effects of PPAR agonists?

被引：4
作者：
Chinetti-Gbaguidi, Giulia
Staels, Bart
机构：
[1] Inst Pasteur, F-59019 Lille, France
[2] INSERM, U545, F-59019 Lille, France
[3] Univ Lille, Fac Sci Pharmaceut & Biol, Fac Med, F-59006 Lille, France
来源：
PHARMACOGENOMICS | 2007年 / 8卷 / 11期
关键词：
D O I：
10.2217/14622416.8.11.1567
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The metabolic syndrome is defined as a clustering of cardiovascular risk factors with insulin resistance, including dyslipidemia, coagulation disturbances and hypertension. Activators of the peroxisome proliferator-activated receptors (PPARs) modulate several of the metabolic risk factors predisposing to atherosclerosis. Fibrates are hypolipidemic drugs acting through activation of PPAR alpha, whereas glitazones are insulin sensitizers activating PPAR gamma. In addition, these drugs exert pleiotropic anti-inflammatory actions. In this review, we will focus on the effects of fibrates and glitazones on biomarker modulation and their usefulness in the treatment of cardiovascular disease.
引用
收藏
页码：1567 / 1580
页数：14
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