The kallikrein-kininogen-kinin system: lessons from the quantification of endogenous kinins

被引：109

作者：

Blais, C

Marceau, F

Rouleau, JL

Adam, A

机构：

[1] Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada

[2] Univ Quebec, Ctr Hosp, Ctr Rech Pavillon Hotel Dieu, Quebec City, PQ G1R 2J6, Canada

[3] Toronto Gen Hosp, Univ Hlth Network, Toronto, ON M5G 2C4, Canada

来源：

PEPTIDES | 2000年 / 21卷 / 12期

关键词：

analytical methods; cardioprotection; endogenous kinins; inflammation; kallikrein-kininogen-kinin system; metabolism;

D O I：

10.1016/S0196-9781(00)00348-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of the present review is to describe the place of endogenous kinins, mainly bradykinin (BK) and des-Arg(9)-BK in the kallikrein-kininogen-kinin system, to review and compare the different analytical methods reported for the assessment of endogenous kinins, to explain the difficulties and the pitfalls for their quantifications in biologic samples and finally to see how the results obtained by these methods could complement and extend the pharmacological evidence of their pathophysiological role. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：1903 / 1940

页数：38

共 427 条

[1]

Abelous JE, 1909, CR SOC BIOL, V66, P511

[2] QUANTIFICATION OF RAT T-KININOGEN USING IMMUNOLOGICAL METHODS - APPLICATION TO INFLAMMATORY PROCESSES [J].