Histopathologic characteristics of autoimmune pancreatitis based on comparison with chronic pancreatitis

被引：34

作者：

Suda, K ^{[1
]}

Takase, M ^{[1
]}

Fukumura, Y ^{[1
]}

Ogura, K ^{[1
]}

Ueda, A ^{[1
]}

Matsuda, T ^{[1
]}

Suzuki, F ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Pathol, Bunkyo Ku, Tokyo 1138421, Japan

来源：

PANCREAS | 2005年 / 30卷 / 04期

关键词：

autoimmune pancreatitis; histopathologic characteristics; lymphoplasmacytic infiltration; fibrosis; obliterative phlebitis;

D O I：

10.1097/01.mpa.0000160283.41580.88

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives: To clarify the histopathologic characteristics of autoimmune pancreatitis (AIP), based on comparison with both chronic alcoholic pancreatitis ( CAP) and chronic obstructive pancreatitis ( COP). Methods: Three AIP patients, 17 CAP patients, and 19 COP patients were studied histopathologically. Results: There was a dense lymphoplasmacytic infiltrate, especially within and around the pancreatic ducts, and fibrosis associated with AIP, while there was fibrosis accompanied by mild inflammatory infiltration in both CAP and COP. Inter- and intralobular fibrosis admixed with acinar atrophy was observed in both AIP and COP, while interlobular fibrosis combined with a "cirrhosis-like'' appearance was found in CAP. Obliterative phlebitis was found in AIP, while thrombosis of the splenic vein was exhibited in CAP. Conclusion: Autoimmune pancreatitis was histologically characterized by dense lymphoplasmacytic infiltrate combined with fibrosis, acinar atrophy, obliterative phlebitis, and ductal involvement.

引用

页码：355 / 358

页数：4

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