Regulatory ripples

被引：22

作者：

Belkaid, Yasmine ^{[1
]}

Chen, WanJun ^{[2
]}

机构：

[1] NIAID, Mucosal Immunol Unit, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Natl Inst Dent & Craniofacial Res, Mucosal Immunol Unit, NIH, Bethesda, MD USA

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 12期

关键词：

T-CELLS; INFECTIOUS TOLERANCE; INDUCTION; CYTOKINE; IL-35;

D O I：

10.1038/ni1210-1077

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells come in many different forms depending on their mode of action or developmental origin. Data now show that interleukin 35, an immunomodulatory cytokine secreted by regulatory T cells, and interleukin 10 induce so-called 'iT(R)35 cells', which may have an important role in the phenomenon of infectious tolerance.

引用

页码：1077 / 1078

页数：2

共 14 条

[1] CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β-dependent manner [J].

Andersson, John ;

Tran, Dat Q. ;

Pesu, Marko ;

Davidson, Todd S. ;

Ramsey, Heather ;

O'Shea, John J. ;

Shevach, Ethan M. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (09) :1975-1981

[2] Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35 [J].

Bardel, Emilie ;

Larousserie, Frederique ;

Charlot-Rabiega, Pascaline ;

Coulomb-L'Hermine, Aurore ;

Devergne, Odile .

JOURNAL OF IMMUNOLOGY, 2008, 181 (10) :6898-6905

[3] Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3 [J].

Chen, WJ ;

Jin, WW ;

Hardegen, N ;

Lei, KJ ;

Li, L ;

Marinos, N ;

McGrady, G ;

Wahl, SM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) :1875-1886

[4] The inhibitory cytokine IL-35 contributes to regulatory T-cell function [J].

Collison, Lauren W. ;

Workman, Creg J. ;

Kuo, Timothy T. ;

Boyd, Kelli ;

Wang, Yao ;

Vignali, Kate M. ;

Cross, Richard ;

Sehy, David ;

Blumberg, Richard S. ;

Vignali, Dario A. A. .

NATURE, 2007, 450 (7169) :566-U19

[5] IL-35-mediated induction of a potent regulatory T cell population [J].

Collison, Lauren W. ;

Chaturvedi, Vandana ;

Henderson, Abigail L. ;

Giacomin, Paul R. ;

Guy, Cliff ;

Bankoti, Jaishree ;

Finkelstein, David ;

Forbes, Karen ;

Workman, Creg J. ;

Brown, Scott A. ;

Rehg, Jerold E. ;

Jones, Michael L. ;

Ni, Hsiao-Tzu ;

Artis, David ;

Turk, Mary Jo ;

Vignali, Dario A. A. .

NATURE IMMUNOLOGY, 2010, 11 (12) :1093-U97

[6] The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation [J].

Koch, Meghan A. ;

Tucker-Heard, Glady's ;

Perdue, Nikole R. ;

Killebrew, Justin R. ;

Urdahl, Kevin B. ;

Campbell, Daniel J. .

NATURE IMMUNOLOGY, 2009, 10 (06) :595-U57

[7]

Niedbala W, 2007, EUR J IMMUNOL, V37, P3021, DOI 10.1002/eji.200737810

[8] Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection [J].

Oldenhove, Guillaume ;

Bouladoux, Nicolas ;

Wohlfert, Elizabeth A. ;

Hall, Jason A. ;

Chou, David ;

Dos Santos, Liliane ;

O'Brien, Shaun ;

Blank, Rebecca ;

Lamb, Erika ;

Natarajan, Sundar ;

Kastenmayer, Robin ;

Hunter, Christopher ;

Grigg, Michael E. ;

Belkaid, Yasmine .

IMMUNITY, 2009, 31 (05) :772-786

[9] INFECTIOUS TRANSPLANTATION TOLERANCE [J].

QIN, SX ;

COBBOLD, SP ;

POPE, H ;

ELLIOTT, J ;

KIOUSSIS, D ;

DAVIES, J ;

WALDMANN, H .

SCIENCE, 1993, 259 (5097) :974-977

[10]

Roncarolo MG, 2006, IMMUNOL REV, V212, P28

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