Regulatory ripples

被引：22

作者：

Belkaid, Yasmine ^{[1
]}

Chen, WanJun ^{[2
]}

机构：

[1] NIAID, Mucosal Immunol Unit, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Natl Inst Dent & Craniofacial Res, Mucosal Immunol Unit, NIH, Bethesda, MD USA

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 12期

关键词：

T-CELLS; INFECTIOUS TOLERANCE; INDUCTION; CYTOKINE; IL-35;

D O I：

10.1038/ni1210-1077

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells come in many different forms depending on their mode of action or developmental origin. Data now show that interleukin 35, an immunomodulatory cytokine secreted by regulatory T cells, and interleukin 10 induce so-called 'iT(R)35 cells', which may have an important role in the phenomenon of infectious tolerance.

引用

页码：1077 / 1078

页数：2

共 14 条

[1] CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β-dependent manner
Andersson, John
Tran, Dat Q.
Pesu, Marko
Davidson, Todd S.
Ramsey, Heather
O'Shea, John J.
Shevach, Ethan M.
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (09) : 1975 - 1981
[2] Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35
Bardel, Emilie
Larousserie, Frederique
Charlot-Rabiega, Pascaline
Coulomb-L'Hermine, Aurore
Devergne, Odile
[J]. JOURNAL OF IMMUNOLOGY, 2008, 181 (10) : 6898 - 6905
[3] Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
Chen, WJ
Jin, WW
Hardegen, N
Lei, KJ
Li, L
Marinos, N
McGrady, G
Wahl, SM
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) : 1875 - 1886
[4] The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Collison, Lauren W.
Workman, Creg J.
Kuo, Timothy T.
Boyd, Kelli
Wang, Yao
Vignali, Kate M.
Cross, Richard
Sehy, David
Blumberg, Richard S.
Vignali, Dario A. A.
[J]. NATURE, 2007, 450 (7169) : 566 - U19
[5] IL-35-mediated induction of a potent regulatory T cell population
Collison, Lauren W.
Chaturvedi, Vandana
Henderson, Abigail L.
Giacomin, Paul R.
Guy, Cliff
Bankoti, Jaishree
Finkelstein, David
Forbes, Karen
Workman, Creg J.
Brown, Scott A.
Rehg, Jerold E.
Jones, Michael L.
Ni, Hsiao-Tzu
Artis, David
Turk, Mary Jo
Vignali, Dario A. A.
[J]. NATURE IMMUNOLOGY, 2010, 11 (12) : 1093 - U97
[6] The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
Koch, Meghan A.
Tucker-Heard, Glady's
Perdue, Nikole R.
Killebrew, Justin R.
Urdahl, Kevin B.
Campbell, Daniel J.
[J]. NATURE IMMUNOLOGY, 2009, 10 (06) : 595 - U57
[7] Niedbala W, 2007, EUR J IMMUNOL, V37, P3021, DOI 10.1002/eji.200737810
[8] Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection
Oldenhove, Guillaume
Bouladoux, Nicolas
Wohlfert, Elizabeth A.
Hall, Jason A.
Chou, David
Dos Santos, Liliane
O'Brien, Shaun
Blank, Rebecca
Lamb, Erika
Natarajan, Sundar
Kastenmayer, Robin
Hunter, Christopher
Grigg, Michael E.
Belkaid, Yasmine
[J]. IMMUNITY, 2009, 31 (05) : 772 - 786
[9] INFECTIOUS TRANSPLANTATION TOLERANCE
QIN, SX
COBBOLD, SP
POPE, H
ELLIOTT, J
KIOUSSIS, D
DAVIES, J
WALDMANN, H
[J]. SCIENCE, 1993, 259 (5097) : 974 - 977
[10] Roncarolo MG, 2006, IMMUNOL REV, V212, P28

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