Synthesis of the first examples of A-C8/C-C2 amide-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

被引：17

作者：

Gregson, SJ ^{[1
]}

Howard, PW ^{[1
]}

Thurston, DE ^{[1
]}

机构：

[1] Univ London, Sch Pharm, Canc Res UK, Gene Targeted Drug Design Res Grp, London WC1N 1AX, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(03)00436-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the synthesis of novel A-C8/C-C2 amide-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers (4a and 4b) via convergent routes. These compounds lack the potent DNA interstrand cross-linking ability and resultant pronounced cytotoxicity of the known A-C8/A-C8' linked dimers (e.g., 2a-b). (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2277 / 2280

页数：4

共 14 条

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Thompson, AS ;

Howard, PW ;

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Croker, SJ ;

Jenkins, TC ;

Neidle, S ;

Hartley, JA ;

Hurley, LH .

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[13]

Thurston DE, 1999, BRIT J CANCER, V80, P65

[14] SYNTHESIS OF DNA-INTERACTIVE PYRROLO[2,1-C][1,4]BENZODIAZEPINES [J].

THURSTON, DE ;

BOSE, DS .

CHEMICAL REVIEWS, 1994, 94 (02) :433-465

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