Understanding the Stony Bridge between Osteoporosis and Vascular Calcification: Impact of the FGF23/Klotho axis

被引：17

作者：

Wei, Xu ^{[1
]}

Huang, Xinyi ^{[2
]}

Liu, Ning ^{[1
]}

Qi, Baoyu ^{[1
]}

Fang, Shengjie ^{[1
]}

Zhang, Yili ^{[3
,4
]}

机构：

[1] China Acad Chinese Med Sci, Wangjing Hosp, Beijing, Peoples R China

[2] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China

[3] Nanjing Univ Chinese Med, Sch Tradit Chinese Med, Nanjing, Peoples R China

[4] Nanjing Univ Chinese Med, Sch Integrated Chinese & Western Med, Nanjing, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2021年 / 2021卷

关键词：

GROWTH-FACTOR; 23; CHRONIC KIDNEY-DISEASE; SMOOTH-MUSCLE-CELLS; AORTIC CALCIFICATION; KLOTHO EXPRESSION; SALUSIN-ALPHA; BONE LOSS; VITAMIN-D; IN-VITRO; PHOSPHATE;

D O I：

10.1155/2021/7536614

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A relationship between osteoporosis (OP) and vascular calcification (VC) is now proposed. There are common mechanisms underlying the regulation of them. Fibroblast growth factor- (FGF-) 23 and Klotho are hormones associated with the metabolic axis of osteovascular metabolism. Most recently, it was suggested that the FGF23-klotho axis is associated with increasing incidence of fractures and is potentially involved in the progression of the aortic-brachial stiffness ratio. Herein, we discussed the potential role of the FGF23/Klotho axis in the pathophysiology of OP and VC. We want to provide an update review in order to allow a better understanding of the potential role of the FGF23/Klotho axis in comorbidity of OP and VC. We believe that a better understanding of the relationship between both entities can help in proposing new therapeutic targets for reducing the increasing prevalence of OP and VC in the aging population.

引用

页数：9

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