Disrupted integrity of the fornix in first-episode schizophrenia

被引：24
作者：
Luck, David [1 ,2 ,3 ]
Malla, Ashok K. [2 ,3 ]
Joober, Ridha [2 ,3 ]
Lepage, Martin [1 ,2 ,3 ]
机构：
[1] Douglas Mental Hlth Univ Inst, Brain Imaging Grp, Verdun, PQ H4H 1R3, Canada
[2] Douglas Mental Hlth Univ Inst, Prevent & Early Intervent Program Psychoses PEPP, Verdun, PQ H4H 1R3, Canada
[3] McGill Univ, Dept Psychiat, Montreal, PQ H3A 2T5, Canada
来源：
SCHIZOPHRENIA RESEARCH | 2010年 / 119卷 / 1-3期
关键词：
DTI; First-episode; Schizophrenia; Tractography; Fornix; ULTRA-HIGH-RISK; HIPPOCAMPAL VOLUME; DIFFUSION; ABNORMALITIES; TRACTOGRAPHY; PSYCHOSIS; DTI;
D O I：
10.1016/j.schres.2010.03.027
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Alterations of the fornix in chronic patients with psychosis are well established, but its integrity in the early stage of schizophrenia remains unknown. Thirty-two patients experiencing first-episode schizophrenia (FES) and 25 matched controls completed a DTI scan. DTI-tractography was used to estimate fractional anisotropy (FA) in bilateral fornices. The analysis showed significant overall FA reductions in the fornix in FES patients relative to controls. No significant correlations were found between FA values and clinical and sociodemographic data in FES patients. These findings revealed slight alterations along the fornix in early stage of schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：61 / 64
页数：4
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