Pre- or post-operative medical treatment with nafarelin in stage III-IV endometriosis: a French multicenter study

被引:39
作者
Audebert, A [1 ]
Descamps, P
Marret, H
Ory-Lavollee, L
Bailleul, F
Hamamah, S
机构
[1] Univ Hosp, Dept Obstet & Gynecol, F-49033 Angers 01, France
[2] Inst Greenblatt France, F-33000 Bordeaux, France
[3] Univ Hosp Bretonneau, Dept Obstet & Gynecol, F-37044 Tours, France
[4] Lab Syntex, F-92807 Puteaux, France
来源
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1998年 / 79卷 / 02期
关键词
endometriosis; medico-surgical treatment; clinical trial;
D O I
10.1016/S0301-2115(98)00028-1
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objectives: To determine the effectiveness of a 6-month course of nafarelin in the treatment of stage III-IV endometriosis and to determine if pre-operative use of nafarelin facilitates surgery. Design: Prospective, multicenter, clinical trial. Setting: Eight university hospitals and two private practice institutions in France. Patients: Fifty-five patients with stage III and IV endometriosis. Two were excluded. Interventions: The severity of endometriosis was assessed at the time of laparoscopy and patients were randomized to have either laparosopic surgery at that time following 6 months of nafarelin therapy (n = 28), or laparoscopic surgery following 6 months of nafarelin therapy (n = 25). All had 200 mu g intranasal nafarelin twice a day for 6 months and a second look laparoscopy. Main outcome measure: Clinical efficacy, tolerance to the treatment. Results: Efficacy and tolerance to the treatment were the same in both groups. AFS scores compared on both laparoscopies were significantly better if nafarelin was given prior to surgery (P = 0.007). Conclusions: This preliminary study shows that in cases of combined medico-surgical treatment for stage III-IV endometriosis, preoperative medical treatment with GnRH-a gives a better AFS score improvement, but no conclusion was possible whether preoperative treatment facilitates surgery. (C) 1998 Elsevier Science Ireland Ltd.
引用
收藏
页码:145 / 148
页数:4
相关论文
共 17 条
[1]   SURGICAL-TREATMENT OF ENDOMETRIOSIS-ASSOCIATED INFERTILITY - METAANALYSIS COMPARED WITH SURVIVAL ANALYSIS [J].
ADAMSON, GD ;
PASTA, DJ .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1994, 171 (06) :1488-1505
[2]  
ADAMSON GD, 1993, FERTIL STERIL, V59, P35
[3]  
*AM FERT SOC, 1985, FERTIL STERIL, V43, P351
[4]  
BATEMAN BG, 1994, FERTIL STERIL, V62, P690
[5]   NAFARELIN IN THE MANAGEMENT OF ENDOMETRIOSIS - QUALITY-OF-LIFE ASSESSMENT [J].
BURRY, KA .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 166 (02) :735-739
[6]  
BUTTRAM VC, 1982, FERTIL STERIL, V37, P478
[7]  
DONNEZ J, 1987, FERTIL STERIL, V48, P239
[8]  
DOSWELL L, 1992, FERTIL STERIL, V57, P514
[10]   EFFICACY AND SAFETY OF NAFARELIN IN THE TREATMENT OF ENDOMETRIOSIS [J].
HENZL, MR ;
KWEI, L .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 162 (02) :570-574