Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype

被引：57

作者：

Federico, Antonella ^{[1
]}

Forzati, Floriana ^{[1
]}

Esposito, Francesco ^{[1
]}

Arra, Claudio ^{[2
]}

Palma, Giuseppe ^{[1
,2
]}

Barbieri, Antonio ^{[2
]}

Palmieri, Dario ^{[1
]}

Fedele, Monica ^{[1
]}

Pierantoni, Giovanna Maria ^{[1
]}

De Martino, Ivana ^{[1
]}

Fusco, Alfredo ^{[1
]}

机构：

[1] Univ Naples Federico II, Fac Med & Chirurg Napoli, Dipartimento Med Mol & Biotecnol Med, Ist Endocrinol & Oncol Sperimentale,CNR, I-80131 Naples, Italy

[2] Fdn Pascale, Ist Nazl Tumori, I-80131 Naples, Italy

来源：

BIOLOGY OPEN | 2014年 / 3卷 / 05期

关键词：

HMGA1; HMGA2; Pygmy; E2F; GENOME-WIDE ASSOCIATION; GROUP A1 PROTEINS; NEOPLASTIC TRANSFORMATION; GENE-EXPRESSION; CELL-CYCLE; IN-VITRO; HMG-I; OVEREXPRESSION; MODULATION; CANCER;

D O I：

10.1242/bio.20146759

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The HMGA1 and HMGA2 genes code for proteins belonging to the High Mobility Group A family. Several genes are negatively or positively regulated by both these proteins, but a number of genes are specifically regulated by only one of them. Indeed, knock-out of the Hmga1 and Hmga2 genes leads to different phenotypes: cardiac hypertrophy and type 2 diabetes in the former case, and a large reduction in body size and amount of fat tissue in the latter case. Therefore, to better elucidate the functions of the Hmga genes, we crossed Hmga1-null mice with mice null for Hmga2. The Hmga1(-/-)/Hmga2(-/-) mice showed reduced vitality and a very small size (75% smaller than the wild-type mice); they were even smaller than pygmy Hmga2-null mice. The drastic reduction in E2F1 activity, and consequently in the expression of the E2F-dependent genes involved in cell cycle regulation, likely accounts for some phenotypic features of the Hmga1(-/-)/Hmga2(-/-) mice.

引用

页码：372 / 378

页数：7

共 45 条

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