Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy

被引：12

作者：

Hanby, Abigail R. ^{[1
]}

Walsh, Stephen J. ^{[1
,2
]}

Counsell, Andrew J. ^{[1
]}

Ashman, Nicola ^{[1
,2
]}

Mortensen, Kim T. ^{[1
]}

Carroll, Jason S. ^{[2
]}

Spring, David R. ^{[1
]}

机构：

[1] Univ Cambridge, Yusuf Hamied Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England

[2] Univ Cambridge, Canc Res UK Cambridge Inst, Robinson Way, Cambridge CB2 0RE, England

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 67期

基金：

英国工程与自然科学研究理事会;

关键词：

All Open Access; Hybrid Gold; Green;

D O I：

10.1039/d2cc02515a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we report the development of a methodology for the dual-functionalisation of IgG antibodies. This is accomplished through the combination of disulfide rebridging divinylpyrimidine technology, with bicyclononyne and methylcyclopropene handles to facilitate sequential SPAAC and IEDDA reactions. Advantageously, the strategy does not require metal catalysis and avoids the need for purification between functionalisation steps.

引用

页码：9401 / 9404

页数：4

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