Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation

被引：275
作者：
Guicheux, J
Lemonnier, J
Ghayor, C
Suzuki, A
Palmer, G
Caverzasio, J [1 ]
机构：
[1] Univ Hosp Geneva, Dept Geriatr, Div Bone Dis, Geneva, Switzerland
[2] Nantes Sch Dent Surg, Res Ctr Mat Biol Interests, Nantes, France
[3] Hop Lariboisiere, INSERM, U349, F-75475 Paris, France
[4] Fujita Hlth Univ, Sch Med, Dept Internal Med, Div Endocrinol, Toyoake, Aichi 47011, Japan
[5] Univ Hosp Geneva, Dept Internal Med, Div Rheumatol, Geneva, Switzerland
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2003年 / 18卷 / 11期
关键词：
bone morphogenetic protein-2; stress-activated protein kinases; p38 mitogen-activated protein kinase; c-jun-NH2-terminal kinase; differentiation;
D O I：
10.1359/jbmr.2003.18.11.2060
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Signaling involved in osteoblastic cell differentiation remains largely unknown. This study further investigates mechanisms involved in BMP-2-induced osteoblastic cell differentiation. We report that BMP-2 can activate JNK and p38 in osteoblastic cells and provide evidences that these MAP kinases have distinct roles in regulating alkaline phosphatase and osteocalcin expression.
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收藏
页码：2060 / 2068
页数：9
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