The effects of inhaled isoparaffins on locomotor activity and operant performance in mice
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作者:
Bowen, SE
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Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA
Bowen, SE
[1
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Balster, RL
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Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA
Balster, RL
[1
]
机构:
[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA
Very little is known qualitatively or quantitatively about the acute central nervous system effects of isoparaffin solvents that are widely used in household and commercial applications. Four isoparaffinic hydrocarbon solvent products differing in predominant carbon number and volatility (ISOPAR-C(TM), -E(TM) -G(TM), -H(TM)) were tested for their acute effects on locomotor activity and operant performance after inhalation exposure in mice. For both measures, concentration-effect curves were obtained for 30-min exposures using a within-subject design. The more volatile products, ISOPAR-C(TM) and -E(TM), were as easily vaporized under our conditions as vapors such as toluene and TCE, which have acute effects on human behavior and are abused. ISOPAR-G(TM) was slowly volatilized and ISOPAR-H(TM) could not be completely volatilized within our 30-min exposures, suggesting that acute human exposures may be less likely and that it may be more difficult to abuse them. ISOPAR-C(TM), -E(TM), and -G(TM) produced reversible increases in locomotor activity of mice at 4000 and 6000 ppm while ISOPAR-C(TM) and -E(TM) produced reversible concentration-dependent decreases in rates of schedule-controlled operant behavior in approximately the same concentration range as they affected locomotor activity. The fact that only locomotor activity increases were observed with these isoparaffins provides evidence that they produce a different pattern of effects than those reported for abused solvents such as toluene and TCE. Further research will be needed to determine if this different pattern of effects on animal behavior between isoparaffins and abused solvents is correlated with a different pattern of acute intoxication and abuse potential in humans. (C) 1998 Elsevier Science Inc.
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Kawasaki Univ Med Welf, Dept Med Technol, 288 Matsushima, Kurashiki, Okayama 7010193, JapanKawasaki Univ Med Welf, Dept Med Technol, 288 Matsushima, Kurashiki, Okayama 7010193, Japan
Ueno, Hiroshi
Takahashi, Yu
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Kawasaki Med Sch, Dept Psychiat, Kurashiki, Okayama, JapanKawasaki Univ Med Welf, Dept Med Technol, 288 Matsushima, Kurashiki, Okayama 7010193, Japan
Takahashi, Yu
Suemitsu, Shunsuke
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Kawasaki Med Sch, Dept Psychiat, Kurashiki, Okayama, JapanKawasaki Univ Med Welf, Dept Med Technol, 288 Matsushima, Kurashiki, Okayama 7010193, Japan
Suemitsu, Shunsuke
Murakami, Shinji
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Kawasaki Med Sch, Dept Psychiat, Kurashiki, Okayama, JapanKawasaki Univ Med Welf, Dept Med Technol, 288 Matsushima, Kurashiki, Okayama 7010193, Japan
Murakami, Shinji
Kitamura, Naoya
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Kawasaki Med Sch, Dept Psychiat, Kurashiki, Okayama, JapanKawasaki Univ Med Welf, Dept Med Technol, 288 Matsushima, Kurashiki, Okayama 7010193, Japan
Kitamura, Naoya
Wani, Kenta
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Kawasaki Med Sch, Dept Psychiat, Kurashiki, Okayama, JapanKawasaki Univ Med Welf, Dept Med Technol, 288 Matsushima, Kurashiki, Okayama 7010193, Japan
Wani, Kenta
Matsumoto, Yosuke
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Okayama Univ, Dept Neuropsychiat, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Okayama, JapanKawasaki Univ Med Welf, Dept Med Technol, 288 Matsushima, Kurashiki, Okayama 7010193, Japan
Matsumoto, Yosuke
Okamoto, Motoi
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Okayama Univ, Dept Med Technol, Grad Sch Hlth Sci, Okayama, Okayama, JapanKawasaki Univ Med Welf, Dept Med Technol, 288 Matsushima, Kurashiki, Okayama 7010193, Japan
Okamoto, Motoi
Ishihara, Takeshi
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Kawasaki Med Sch, Dept Psychiat, Kurashiki, Okayama, JapanKawasaki Univ Med Welf, Dept Med Technol, 288 Matsushima, Kurashiki, Okayama 7010193, Japan
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Wayne State Univ, Dept Psychol, Detroit, MI 48202 USAWayne State Univ, Dept Psychol, Detroit, MI 48202 USA
Batis, Jeffery C.
Hannigan, John H.
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Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA
Wayne State Univ, Merrill Palmer Skillman Inst Child & Family Dev, Detroit, MI 48202 USA
Wayne State Univ, Dept Obstet & Gynecol, Detroit, MI 48202 USAWayne State Univ, Dept Psychol, Detroit, MI 48202 USA
Hannigan, John H.
Bowen, Scott E.
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Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA
Wayne State Univ, Behav Pharmacol & Toxicol Lab, Detroit, MI 48202 USA
Wayne State Univ, Dept Obstet & Gynecol, Detroit, MI 48202 USAWayne State Univ, Dept Psychol, Detroit, MI 48202 USA