The effects of inhaled isoparaffins on locomotor activity and operant performance in mice

被引:17
|
作者
Bowen, SE [1 ]
Balster, RL [1 ]
机构
[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA
关键词
solvents; inhalant abuse; isoparaffins; operant behavior; locomotor activity; toxicology;
D O I
10.1016/S0091-3057(98)00108-7
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Very little is known qualitatively or quantitatively about the acute central nervous system effects of isoparaffin solvents that are widely used in household and commercial applications. Four isoparaffinic hydrocarbon solvent products differing in predominant carbon number and volatility (ISOPAR-C(TM), -E(TM) -G(TM), -H(TM)) were tested for their acute effects on locomotor activity and operant performance after inhalation exposure in mice. For both measures, concentration-effect curves were obtained for 30-min exposures using a within-subject design. The more volatile products, ISOPAR-C(TM) and -E(TM), were as easily vaporized under our conditions as vapors such as toluene and TCE, which have acute effects on human behavior and are abused. ISOPAR-G(TM) was slowly volatilized and ISOPAR-H(TM) could not be completely volatilized within our 30-min exposures, suggesting that acute human exposures may be less likely and that it may be more difficult to abuse them. ISOPAR-C(TM), -E(TM), and -G(TM) produced reversible increases in locomotor activity of mice at 4000 and 6000 ppm while ISOPAR-C(TM) and -E(TM) produced reversible concentration-dependent decreases in rates of schedule-controlled operant behavior in approximately the same concentration range as they affected locomotor activity. The fact that only locomotor activity increases were observed with these isoparaffins provides evidence that they produce a different pattern of effects than those reported for abused solvents such as toluene and TCE. Further research will be needed to determine if this different pattern of effects on animal behavior between isoparaffins and abused solvents is correlated with a different pattern of acute intoxication and abuse potential in humans. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:271 / 280
页数:10
相关论文
共 50 条
  • [1] Effects of inhaled 1,1,1-trichloroethane on locomotor activity in mice
    Bowen, SE
    Balster, RL
    NEUROTOXICOLOGY AND TERATOLOGY, 1996, 18 (01) : 77 - 81
  • [2] EFFECTS OF THYROTROPIN-RELEASING-HORMONE ON LOCOMOTOR-ACTIVITY, OPERANT PERFORMANCE AND INGESTIVE BEHAVIOR
    VOGEL, RA
    COOPER, BR
    BARLOW, TS
    PRANGE, AJ
    MUELLER, RA
    BREESE, GR
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1979, 208 (02): : 161 - 168
  • [3] DIFFERENTIAL SENSITIVITY TO THE EFFECTS OF ALBUTEROL ON LOCOMOTOR-ACTIVITY AND OPERANT-BEHAVIOR
    ODONNELL, JM
    PSYCHOPHARMACOLOGY, 1993, 113 (02) : 243 - 249
  • [4] Caffeine inhalation effects on locomotor activity in mice
    Ueno, Hiroshi
    Takahashi, Yu
    Suemitsu, Shunsuke
    Murakami, Shinji
    Kitamura, Naoya
    Wani, Kenta
    Matsumoto, Yosuke
    Okamoto, Motoi
    Ishihara, Takeshi
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2020, 46 (05) : 788 - 794
  • [5] EFFECTS OF MPTP ON LOCOMOTOR-ACTIVITY IN MICE
    COLOTLA, VA
    FLORES, E
    OSCOS, A
    MENESES, A
    TAPIA, R
    NEUROTOXICOLOGY AND TERATOLOGY, 1990, 12 (04) : 405 - 407
  • [6] Aluminum effects on operant performance and food motivation of mice
    Golub, MS
    Germann, SL
    NEUROTOXICOLOGY AND TERATOLOGY, 1998, 20 (04) : 421 - 427
  • [7] Differential effects of inhaled toluene on locomotor activity in adolescent and adult rats
    Batis, Jeffery C.
    Hannigan, John H.
    Bowen, Scott E.
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2010, 96 (04) : 438 - 448
  • [8] The effects of norepinephrine transporter inactivation on locomotor activity in mice
    Mitchell, Heather A.
    Ahern, Todd H.
    Liles, L. Cameron
    Javors, Martin A.
    Weinshenker, David
    BIOLOGICAL PSYCHIATRY, 2006, 60 (10) : 1046 - 1052
  • [9] EFFECTS OF DIABETES ON SPONTANEOUS LOCOMOTOR-ACTIVITY IN MICE
    KAMEI, J
    SAITOH, A
    IWAMOTO, Y
    FUNADA, M
    SUZUKI, T
    MISAWA, M
    NAGASE, H
    KASUYA, Y
    NEUROSCIENCE LETTERS, 1994, 178 (01) : 69 - 72